滋阴清热方对复发性口腔溃疡患者炎性因子的影响  

Influence of Ziyinqingre Fang for Recurrent Oral Ulcers Inflammatory Factors

作　　者：刘春子[1] 李萍[1] 米宏图[1] 葛风华[1] 

机构地区：[1]广东省深圳市宝安区中医院,广东深圳518133

出　　处：《中国医学创新》2016年第23期105-108,共4页Medical Innovation of China

摘　　要：目的:探究滋阴清热方对复发性口腔溃疡患者炎性因子的影响。方法:选择2011年6月-2015年7月年在本院收治的复发性口腔溃疡患者44例作为研究对象,将其按照随机数字表法分为研究组24例和对照组20例。研究组采用滋阴清热方进行临床治疗,对照组采用复合维生素B、左旋咪唑片进行临床治疗,观察治疗前后患者血浆IL-2、IL-8、TNF-α水平的变化情况;比较患者溃疡面积,充血面积;比较患者免疫功能,血浆内皮素-1指标。结果:治疗12周后,两组患者的血浆IL-2、IL-8、TNF-α水平与治疗前比较均有改善(P<0.05);治疗12周后,研究组患者的血浆IL-2、IL-8、TNF-α水平明显优于对照组,差异均有统计学意义(P<0.05)。治疗6 d后,研究组溃疡及充血面积缩小均优于对照组,差异均有统计学意义(P<0.05)。发病期间患者外围血中CD3+、CD4+、CD8+、CD56+、CD4+/CD8+的细胞百分比方面,研究组均明显高于对照组,差异均有统计学意义(P<0.05);研究组全血黏度、血浆黏度、全血还原黏度、血沉、红细胞聚集指数等各项血浆内皮素-1指标均明显优于对照组,差异均有统计学意义(P<0.05);两组患者的总有效率比较差异有统计学意义(P<0.05)。结论:滋阴清热方可以显著降低复发性口腔溃疡患者的炎性水平,疗效安全可靠,成果显著,价格较低,值得临床上的大力推广和应用。Objective：To investigate the influence of Ziyinqingre Fang for patients with recurrent oral ulcers inflammatory factors.Method：From June 2011 to July 2015,44 cases of recurrent oral ulcers in our hospital were selected as research objects,they were randomly divided into study group（n=24） and control group （n=20）.The study group used Ziyinqingre Fang treatment,the control group used Complex Vitamins B, Levamisole Tablets for clinical treatment.Changes in plasma IL-2,IL-8 before and after treatment,TNF-α, ulcer area,congestion area were measured and recorded.Two groups of patients immune function,plasma endothelin-1 index were analyzed and compared.Result：After treatment for 12 weeks,both groups of patients with plasma IL-2,IL-8,TNF-α levels compared with before treatment were improved（P〈0.05）,after treatment for 12 weeks,the study group of patients with plasma IL-2,IL-8,TNF-α were significantly better than the control group,the differences were statistically significant （P〈0.05）.After the treatment of 6 days, the study group ulcers and congestion area reduced than the control group,the differences were statistically significant （P〈0.05）.During the onset of oral ulcers,peripheral blood of the CD3＋,CD4＋,CD8＋,CD56＋, CD4＋/CD8＋ cell percentage of the study group were significantly higher than the control group,the differences were statistically significant （P〈0.05）.Whole blood viscosity,plasma viscosity,the plasma endothelin-1 indexes whole blood reduced viscosity,erythrocyte sedimentation rate,erythrocyte aggregation index of the study group were significantly better than the control group,the differences had statistics significance （P〈0.05）.The total effective rate between the two groups was compared,the difference had statistical significance （P〈0.05）. Conclusion：Ziyinqingre Fang can significantly reduce levels of inflammatory recurrent oral ulcers,the clinical efficacy and safety,reliable,remarkable achievements,lower prices,should be vigorously pro

关 键 词：滋阴清热方 复发性口腔溃疡 炎性因子 

分 类 号：R276.8[医药卫生—中医五官科学]