量子点室温磷光探针检测生物体液中的头孢哌酮钠舒巴坦钠  

Detection of Cefoperazone Sodium and Sulbactam Sodium in Biological Fluid by Quantum Dots Room Temperature Phosphorescence Probe

作　　者：房晓星 郑吉[1] 闫桂琴[1] 

机构地区：[1]山西师范大学生命科学学院,临汾041000

出　　处：《高等学校化学学报》2016年第8期1435-1441,共7页Chemical Journal of Chinese Universities

基　　金：国家教育部博士点联合基金(批准号:20111404110002);山西省重点化学优势学科建设项目(批准号:912019)资助~~

摘　　要：以水相合成的3-巯基丙酸包覆的Mn掺杂Zn S量子点（MPA-Mn/Zn S QDs）作为室温磷光探针,基于头孢哌酮钠舒巴坦钠（CPZ-SBT）作为一种电子受体,可通过电子转移有效猝灭Mn/Zn S QDs的室温磷光效应,构建了一种测定痕量CPZ-SBT的方法.当CPZ-SBT浓度为0.7~84μg/L时,其与MPA-Mn/Zn S QDs的磷光强度之间呈良好线性关系,相关系数为0.99,该方法的检出限为0.14μg/L.A method for the determination of trace cefoperazone sodium-sulbactam sodium（ CPZ-SBT） was established using water phase synthesized 3-mercaptopropionic acid-capped Mn-doped Zn S quantum dots（ MPA-Mn/Zn S QDs） as a room temperature phosphorescence（ RTP） probe,which based on the phenomenon that the electron acceptor acted by CPZ-SBT can effectively quench the RTP of MPA-Mn/Zn S QDs through electron transfer. There is a good relationship between CPZ-SBT and changes on the phosphorescence intensity of MPA-Mn/Zn S QDs when the concentration of CPZ-SBT is in the scope of 0. 7—84 μg/L. The correlation coefficient and detection limit of this method are 0. 99 and 0. 14 μg/L,respectively. Additionally,this method is able to conduct analysis simply without deoxidizer,inducer or complex sample processing,which can effectively avoid the interference of background fluorescence and scattered light in biological fluids and can be successfully applied in trace determination of CPZ-SBT in biological fluids as well.

关 键 词：量子点 室温磷光探针 检测 头孢哌酮钠舒巴坦钠 

分 类 号：O657.3[理学—分析化学]