二维剪切波成像诊断慢性乙型肝炎肝纤维化不同取值方法的对比研究  

The Comparative Study of Two-dimensional Shear Wave Elastography for Assessing Hepatic Fibrosis in Chronic Hepatitis B Using Different Taking Value Methods

作　　者：曾婕[1] 郑剑[1] 黄泽萍[1] 吴涛[1] 郑荣琴[1] 

机构地区：[1]中山大学附属第三医院超声科,广州市510630

出　　处：《中国超声医学杂志》2016年第8期717-720,共4页Chinese Journal of Ultrasound in Medicine

基　　金：广东省医学科学技术研究基金项目(No.B2014148)

摘　　要：目的探讨二维剪切波弹性成像诊断慢性乙型肝炎肝纤维化测量数据最佳取值方法。方法分析175例慢性乙型肝炎肝纤维化患者二维剪切波弹性成像肝脏弹性测值,以肝穿刺结果为诊断标准,比较采用均值和中位数两种不同测量数据的取值方法对慢性乙型肝炎肝纤维化分期的诊断价值。结果以均值为取值方法诊断显著性肝纤维化、严重肝纤维化和肝硬化的受试者工作特征曲线下面积分别为0.916、0.939和0.950,以中位数为取值方法分别为0.913、0.936和0.943,以均值为取值方法的受试者工作特征曲线下面积均稍高于以中位数为取值方法,但两者无显著性差异(均P>0.05)。结论建议采用测量数据的均值作为检查结果诊断慢性乙型肝炎肝纤维化分期。Objective To explore the best taking value method of two-dimensional shear wave elastography（2DSWE）for assessing hepatic fibrosis in chronic hepatitis B（CHB）.Methods The liver stiffness measurements by 2DSWE of 175 patients with CHB infection were analyzed.The mean and the median of measurement values of two different taking value methods for the diagnosis of liver fibrosis stages in chronic hepatitis B were compared,using liver biopsy as the reference standard.Results The areas under the receiver-operating characteristic（ROC）curves of the mean of measurement values for diagnosing significant fibrosis,severe fibrosis and cirrhosis were 0.916,0.939and0.950.The areas under ROC curves of the median of measurement values were 0.913,0.936 and 0.943.The areas under ROC curves of the mean of measurement values were higher than those of the median of measurement values.However,there were no significant differences（all P〉0.05）.Conclusions The use of the mean of measurement values for diagnosing liver fibrosis stages is recommended.

关 键 词：超声 肝纤维化 弹性成像 剪切波 

分 类 号：R445.1[医药卫生—影像医学与核医学] R512.62[医药卫生—诊断学] R575.2[医药卫生—临床医学]