右美托咪定对丙泊酚麻醉下无抽搐电休克治疗患者麻醉恢复质量的影响  

Effect of dexmedetomidine on quality of recovery from anesthesia in patients undergoing modified electroconvulsive therapy with propofol anesthesia

作　　者：李响[1] 郭娜[1] 程楠[1] 周少丽[1] 黑子清[1] 

机构地区：[1]中山大学附属第三医院麻醉科,广州市510630

出　　处：《中华麻醉学杂志》2016年第4期430-432,共3页Chinese Journal of Anesthesiology

摘　　要：目的评价右美托咪定对丙泊酚麻醉下无抽搐电休克治疗患者麻醉恢复质量的影响。方法择期行无抽搐电休克治疗的患者110例，性别不限，年龄18～50岁，体重45～80kg，ASA分级Ⅰ或Ⅱ级，采用随机数字表法分为2组（n=55）：对照组（C组）和右美托咪定组（D组）。D组经10min静脉输注右美托咪定0．5μg／kg（用生理盐水稀释至10m1），C组经10min静脉输注生理盐水10ml。然后2组静脉注射丙泊酚1．5mg／kg和琥珀胆碱0．5mg／kg，并行尢抽搐电休觅治疗。汜求苏醒时间、麻醉恢复期心血管事件、恶心呕吐、呼吸抑制、头痛、嗜睡、躁动的发生情况。结果与C组比较，D组麻醉恢复期恶心呕吐、头痛和躁动的发生率降低（P〈0．05），苏醒时间、高血压、心动过速、呼吸抑制和嗜睡的发生率差异无统计学意义（P〉0．05）。结论右美托咪定（麻醉前经10min静脉输注0．5μg／kg）可提高丙泊酚麻醉下无抽搐电休克治疗患者麻醉恢复质量。Objective To evaluate the effect of dexmedetomidine on the quality of recovery from anesthesia in the patients undergoing modified electroconvulsive therapy （MECT） with propofol anesthesia. Methods One hundred and ten patients of both sexes, aged 18-50 yr, weighing 45-80 kg, of American Society of Anesthesiologists physical status Ⅰ or Ⅱ , scheduled for elective MECT with general anesthesia, were randomly assigned into 2 groups （ n = 55 each） using a random number table ： control group （ group C） and dexmedetomidine group （group D）. Dexmedetomidine was infused intravenously in a dose of 0.5μg/kg （in normal saline 10 ml） over 10 min in group D, while normal saline 10 ml was infused intravenously over 10 rain in group C. Propofol 1.5 mg/kg and suecinylcholine 0.5 mg/kg were injected intravenously, and MECT was performed in the two groups. The emergence time was recorded. The development of cardiovascular events, nausea and vomiting, respiratory depression, headache, somnolence and agitation during recovery from anesthesia was recorded. Results Compared with group C, the incidence of nausea and vomiting, headache and agitation during recovery from anesthesia was significantly decreased （ P〈 0.05） , and no significant changes were found in the emergence time, and incidence of hypertension, tachycardia, respiratory depression and somnolence during recovery from anesthesia in group D （P〉 0.05）. Conclusion Dexmedetomidine （intravenously infused in a dose of 0.5 μg/kg over 10 rain before anesthesia） can raise the quality of recovery from anesthesia in the patients undergoing MECT with propofol anesthesia.

关 键 词：右美托咪啶 二异丙酚 电惊厥疗法 麻醉恢复期 

分 类 号：R614[医药卫生—麻醉学]