尿足细胞标志蛋白Podocalyxin、Mindin水平与糖尿病视网膜病变的关系  

The Relationship of Urinary Podocyte Marker Protein Podocalyxin and Mindin with Diabetic Retinopathy

作　　者：邵雪景[1] 韦玉和[1] 冯小芬[1] 赵志勇[1] 印永 

机构地区：[1]江苏省常州市武进人民医院内分泌科,常州213000

出　　处：《微循环学杂志》2016年第3期54-57,共4页Chinese Journal of Microcirculation

摘　　要：目的:探讨2型糖尿病(T2DM)患者尿足细胞标记蛋白Podocalyxin(PCX)、Mindin(MIN)与糖尿病视网膜病变(DR)的关系。方法:选择90例T2DM患者(A组),依据视网膜病变程度分为3个亚组:糖尿病无DR组(A1组,n=36)、非增生型DR组(A2组,n=29)和增生型DR组(A3组,n=25);另选32名健康体检者作为对照组(B组)。平行测定各组尿PCX、MIN、血肌酐(Scr)和尿肌酐(Ucr),计算尿PCX相对值(PCR=尿PCX/Ucr)、尿MIN相对值(MCR=尿MIN/Ucr)和肾小球滤过率(eGFR),比较各组各指标差异及其相关性。结果:各组PCR、MCR、Scr、eGFR差异均有统计学意义(P<0.01)。A组各亚组MCR、PCR、Scr显著高于B组,eGFR显著低于B组(均P<0.05);MCR、PCR从A1-A3组逐渐递增(P<0.05)。PCR与MCR呈正相关(P<0.05);PCR、MCR与DR分级呈正相关(P<0.05),且均与Scr呈正相关(P<0.05),与eGFR呈负相关(P<0.05)。结论:尿PCX、MIN水平升高与DR有关,可作为DM微血管病变观察、治疗的新靶标。Objective：To investigate the relationship of urinary podocyte marker protein podocalyxin（PCX）and mindin（MIN）with diabetic retinopathy（DR）.Method：To choice 90 cases of patients with type 2diabetes as the case group（group A）,another 32 healthy volunteers as control group（group B）.On the basis of the presence of retinopathy,group A was assigned into three subgroups,without diabetic retinopathy（A1,n=36）,non-proliferative diabetic retinopathy（A2,n=29）and diabetic retinopathy（A3,n=25）.We measured the levels of urinary PCX,MIN,urine creatinine（Ucr）in parallel,calculated the relative value of PCX（PCR=PCX/Ucr）,MIN relative value（MCR=MIN/Ucr）,glomerular filtration rate（eGFR）,and compared the differences of each index and their correlation.Results：The differences of PCR,MCR,serum creatinine（Scr）and eGFR were statistically significant（P〈0.05）in each group.The level of MCR,PCR and Scr in each sub gruoup of A was significantly higher than that of B group,eGFR was significantly lower than that of B group（P〈0.05）.PCR,MCR from the A1-A3 group gradually increased（P〈0.05）.PCR was positively correlated with MCR（P〈0.05）,PCR,MCR were positively correlated with DR classification（P〈0.05）,and were positively correlated with Scr（P〈0.05）,and negatively correlated with eGFR（P〈0.05）.Conclusion：Urinary PCX,MIN levels were associated with DR,which can be a new target for the treatment of DM microvascular lesions.

关 键 词：PODOCALYXIN Mindin 糖尿病视网膜病变 

分 类 号：R587.2[医药卫生—内分泌]