中性粒细胞和淋巴细胞比率与急性心肌梗死患者心室重构及预后的相关性  

Relationship between neutrophil/lymphocyte ratio and ventricular remodeling and prognosis in patients with acute myocardial infarction

作　　者：李宾[1] 刘静[2] 刘姝莉[1] 黄俊[1] 葛雄[1] 甘受益[1] 

机构地区：[1]咸宁市中心医院湖北科技学院附属第一医院心内科 [2]咸宁市中心医院湖北科技学院附属第一医院检验科,湖北咸宁437100

出　　处：《中日友好医院学报》2016年第4期225-228,232,共5页Journal of China-Japan Friendship Hospital

摘　　要：目的：探讨急性心肌梗死（AMI）患者血液中性粒细胞和淋巴细胞比率（NLR）与心室重构及预后的关系。方法：选取2012年4月~2014年4月入院的105例AMI患者,40例健康体检者为对照组,检测各组血液NLR值。给予患者静脉溶栓及延期PCI术治疗。分别于溶栓后1周及PCI术后6个月采用超声心动图测量并计算左室舒张末期容积指数（LVEDVI）,计算△LVEDVI值,根据其值≥20%与否分为AMI伴心室重构（VR）,观察AMI患者主要心血管不良事件（MACE）的发生率。结果：AMI伴心室重构（VR组）40例,不伴心室重构（NVR）组65例。NVR组和VR组血液NLR值均显著高于对照组（P〈0.01）;VR组血液NLR值显著高于NVR组（P〈0.01）;多因素Logistic回归分析结果,血液NLR值是AMI心室重构的独立危险因素（OR=9.92,P〈0.01）;VR组MACE发生率显著高于NVR组（P〈0.01）。结论：AMI患者血液NLR值与心室重构及预后相关。Objective：To investigate the relationship between value of neutrophil/lymphocyte ratio（NLR）and ventricular remodeling and prognosis in patients with acute myocardial infarction（AMI）.Methods：One hundred and five patients with AMI who hospitalized from April 2012 to April 2014（AMI group）and 40 cases of healthy people（CON）were included.The peripheral blood neutrophil leucocytes and lymphocytes were measured prior to intervention and NLR was calculated.Patients were treated with intravenous thrombolysis and percutaneous coronary intervention（PCI）.One week after intravenous thrombolysis and 6 months after PCI,echocardiography was used to measure left ventricular end diastolic volume index（LVEDVI）.The change of LVEDVI（△LVEDVI） was used to define ventricular remodeling with cut-off value 20%.The incidence of major adverse cardiovascular event（MACE）was recorded.Results：Forty cases of AMI had ventricular remodeling（VR group）and 65 cases did not have VR（NVR group）.The value of NLR in the two groups were significantly higher than that in CON group（P〈0.01）.It was significantly higher in VR group than in NVR group（P〈0.01）.Multivariate logistic regression analysis showed that NLR was an independent risk factor for ventricular remodeling in patients with AMI（P〈0.01）.The incidence of MACE in VR group were significantly higher than NVR group（P〈0.01）.Conclusion：A higher value of NLR was associated with ventricular remodeling.

关 键 词：急性心肌梗死 中性粒细胞和淋巴细胞比率 心室重构 主要心血管不良事件 

分 类 号：R542.22[医药卫生—心血管疾病]