乳酸菌阴道胶囊联合氟康唑对念球菌性阴道炎疗效及炎性因子的影响  

The impact of efficacy and inflammatory factors of Lactobacillus vaginal capsules Fluconazole against Candida vaginitis

作　　者：李竹[1] 郭静[1] 林林[1] 李丽[1] 韩雪[1] 

机构地区：[1]辽宁省铁岭市中心医院妇产科,112000

出　　处：《疑难病杂志》2016年第8期834-837,共4页Chinese Journal of Difficult and Complicated Cases

摘　　要：目的探讨乳酸菌阴道胶囊联合氟康唑治疗念球菌性阴道炎的疗效及其对血清C反应蛋白（CRP）、白介素-6（IL-6）及肿瘤坏死因子-α（TNF-α）的影响。方法选取2014年6月—2015年6月确诊为念珠菌性阴道炎患者120例为研究对象,根据抽签法将患者随机分为观察组及对照组各60例,对照组口服氟康唑治疗,每次150 mg,每天1次;观察组在对照组基础上加用乳酸菌阴道胶囊,阴道上药,每晚2粒,连用7d,2组持续治疗14 d,观察2组患者临床治疗效果及治疗前后血清中CRP、IL-6及TNF-α水平的变化。结果观察组临床总有效率为96.67%（58/60）,对照组为80.00%（48/60）,2组比较差异有统计学意义（χ^2=8.086,P〈0.05）。观察组治疗后阴道瘙痒感、疼痛感、阴道分泌物、黏膜充血性水肿等症状评分显著低于对照组（t=10.264、7.826、10.480、7.217,P〈0.05）。观察组治疗后乳酸杆菌阳性率（91.67%）显著高于对照组（75.00%）,差异有统计学意义（χ^2=6.000,P〈0.05）,而念珠菌阳性率（11.67%）、复发率（16.67%）均显著低于对照组（26.67%）、（11.67%）,差异有统计学意义（χ^2=7.610、4.821,P〈0.05）。观察组治疗后血清CRP、IL-6及TNF-α水平分别为（3.78±0.78）ng/ml、（2.25±0.54）pg/L、（25.36±10.22）9g/L,均显著低于对照组（5.88±1.02）ng/ml、（5.55±1.36）pg/L、（85.98±8.36）pg/1.（t=12.668、17.469、35.563,P〈0.01）。结论乳酸菌阴道胶囊联合氟康唑能有效调节阴道菌群失调情况,降低患者阴道炎性因子水平,提高治疗效果,降低复发率。Objective To investigate the impact of efficacy and the levels of serum C reactive protein （ CRP） , inter-leukin 6 （IL-6） and tumor necrosis factor （TNF-α） of Lactobacillus vaginal capsules Fluconazole against Candida vaginitis. Methods 120 cases of patients diagnosed with candida vaginitis were divided into observation group （ n =60） and control group （ n =60） from June 2014 to June 2015.The control group were treated with oral fluconazole, each 150 mg, 1 times a day.The observation group were treated with lactobacillus vaginal capsules, vaginal drugs, night two, once every 7d, two groups were continued therapy 14 d.The levels of CRP, IL-6 .TNF-αof two groups were compared.Results The total effec-tive rate of observation group was 96.67%, and control group was 80.00% （χ^2 =8.086, P 〈0.05）.The vaginal itching, pain, vaginal secretions, mucosal congestion and edema and other symptoms score of observation group after treatment were lower than control group （ t =10.264, t =7.826, t =10.480, t =7.217, P 〈0.05）.Lactobacillus positive rate （91.67%） was significantly higher than control groups （75.00%）, the difference in the observation group after treatment was statistically significant （χ^2 =6.000, P 〈0.05）, while Candida positive rate （11.67%）, the recurrence rate （16.67%） was significantly lower than the control group （26.67%）, （11.67%）（χ^2 =7.610,χ^2 =4.821, P 〈0.05）.The levels of the levels of CRP, IL-6, TNF-αof observation group after treatment were （3.78 ±0.78） ng/ml, （2.25 ±0.54） pg/L, （25.36 ±10.22）pg/L, which was significantly lower than the control group （5.88 ±1.02） ng/ml, （5.55 ±1.36） pg/L, （85.98 ±8.36） pg/L（ t =12.668, t =17.469, t =35.563, P 〈0.05）.Conclusion Lactobacillus vaginal capsules Flu-conazole can effectively regulate the vaginal flora circumstances, to reduce inflammation in patients with vaginal secretions CRP, IL-6 TNF-αlevels and improve patient outcomes, reduce postoperative recu

关 键 词：乳酸菌阴道胶囊 氟康唑 念球菌性阴道炎 血清C反应蛋白 白细胞介素-6 肿瘤坏死因子-Α 

分 类 号：R711.31[医药卫生—妇产科学]