丙硫氧嘧啶治疗妊娠伴甲状腺功能亢进症对其甲状腺功能及新生儿的影响  

Effects of propylthiouracil in treating pregnancy with hyperthyroidism on their thyroid function and newborns

作　　者：朱永宁[1] 尹国才[1] 谢宁[1] 李华菊[1] 郭丽珠[1] 

机构地区：[1]山东省济宁医学院附属医院产科,272129

出　　处：《疑难病杂志》2016年第8期838-840,844,共4页Chinese Journal of Difficult and Complicated Cases

摘　　要：目的观察丙硫氧嘧啶治疗妊娠伴甲状腺功能亢进症对其甲状腺功能以及新生儿的影响。方法选择2010年6月—2015年8月济宁医学院附属医院产科接受治疗的伴有甲状腺功能亢进的妊娠期女性患者108例,根据患者的意愿将其分为观察组和对照组各54例。对照组患者不应用抗甲状腺类药物进行治疗,观察组患者应用丙硫氧嘧啶予以治疗。观察比较2组患者的甲状腺激素水平、新生儿以及并发症情况等。结果治疗后,观察组患者的TT_3、TT_4、FT_3、FT_4水平均低于对照组[(1.9±0.2)nmol/L、(148.6±22.7)nmol/L、(6.5±0.8)pmol/L、(21.4±2.6)pmol/L vs.(3.5±14)nmol/L、(296.3±31.9)nmol/L、(23.7±1.3)pmol/L、(55.8±3.0)pmol/L,P<0.05],TSH水平高于对照组[(2.25±0.29)mU/L vs.(0.11±0.02)mU/L,P<0.05];新生儿体质量以及Apgar评分高于对照组[(3 026.8±215.7)g、(9.4±0.5)分vs.(2 188.9±186.3)g、(7.6±0.4)分,P<0.05];并发症少于对照组(P<0.05)。结论丙硫氧嘧啶应用于妊娠期甲状腺功能亢进可显著改善患者的甲状腺功能,提高新生儿体质量,并且具有较少的并发症。Objective To analyze and investigate the effects of propylthiouracil in treating pregnancy with hyperthy-roidism on their thyroid function and newborns.Methods One hundred and eight cases of patients with hyperthyroidism in pregnancy treated in our hospital from June 2010 to August 2015 were selected, and were divided into the observation group （54 cases） and the control group （54 cases） according to their wishes.The patients of control group were treated without anti-thyroid drugs,while the patients of observation group were treated with antithyroid drug propylthiouracil.Thyroid hormone lev-els, newborns and complications of the two groups were observed and compared.Results After appropriate treatment, the levels of TT3,TT4,FT3, FT4 of observation group were all significantly lower than those of control group[（1.9 ±0.2）nmol/L, （148.6 ±22.7）nmol/L, （6.5 ±0.8）pmol/L, （21.4 ±2.6）pmol/L vs.（3.5 ±1.4）nmol/L, （296.3 ±31.9）nmol/L, （23.7 ±1.3）pmol/L, （55.8 ±3.0） pmol/L, P 〈0.05]; The levels of TSH of observation group were significantly better than those of control group[（2.25 ±0.29）mU/L vs.（0.11 ±0.02）mU/L, P 〈0.05];The fetal weight and Apgar score of observation group were significantly better than those of control group （ P 〈0.05）; The complications of observation group were significantly less than those of control group （ P 〈0.05）.Conclusion In treating patients with hyperthyroidism in pregnancy, propylthiouracil can significantly improve the thyroid function of patients, improve fetal weight and get fewer com-plications, which indicates that it has an important clinical significance.

关 键 词：妊娠 甲状腺功能亢进 丙硫氧嘧啶 新生儿 

分 类 号：R714.256[医药卫生—妇产科学]