ICAM-3蛋白表达在预测宫颈癌放射抵抗性中的价值  

作　　者：沙红兰 何陈云[2] 李咏[2] 刘蓉[2] 何爱琴[2] 

机构地区：[1]江苏省如皋市人民医院,226500 [2]南通大学附属肿瘤医院,226361

出　　处：《浙江临床医学》2016年第9期1575-1577,共3页Zhejiang Clinical Medical Journal

基　　金：江苏省南通市卫生科技计划项目（20112KX11008）

摘　　要：目的探讨细胞间粘附分子．3（ICAM-3）、血管内皮生长因子（VEGF）的蛋白表达水平与宫颈鳞癌放射抵抗性的相关性。方法采用免疫组织化学S．P法检测90例中晚期宫颈鳞癌患者癌组织中ICAM．3和VEGF的蛋白表达，所有患者均采用同步放化疗。其中25例为放疗后未控，65例为放疗后缓解。结果ICAM．3在90例宫颈鳞癌组织中的阳性表达54例（60．0％）；VEGF呈阳性表达56例（62．2％）。ICAM-3在宫颈鳞癌放疗后未控组中的阳性表达率84．0％，放疗后缓解组中的阳性表达率50．8％，两组差异有统计学意义（P=0．008）；VEGF在宫颈鳞癌放疗后未控组中的阳性表达率80．0％，放疗后缓解组中的阳性表达率55．4％，两组差异有统计学意义（P=0．031）。ICAM-3和VEGF高表达均与肿瘤病理分级及淋巴结转移显著相关，而与临床分期无明显相关性。结论ICAM．3、VEGF蛋白高表达与宫颈鳞癌放射抵抗性相关，可作为预测宫颈癌放疗敏感性的指标。Objective To study the relationship between Intercellular Adhesion Molecule-3、Vascular endothelial growth factor With radioresistance of human cervical squamous cancer. Methods S-P immunohistochemical method was performed to detect the expression of ICAM-3 and VEGF in 90 patients with advanced cervical squamous cell carcinoma, of which 25 cases were non-weU treated after radiotherapy, 65 cases were well treated after radiotherapy. Result The positive expression level of ICAM-3 and VEGF were related to clinical stage and lymph nodes metastasis; The expression level of ICAM-3 in non-well treated group was higher than that in well treated group （ 84.0% vs 50.8%, P=0.008 ） . The expression level of VEGF in non-well treated group was higher than that in well treated group （ 80.0% vs 55.4%, P=0.031 ） . The expression oflCAM-3 and VEGF were significantly related to lymph node metastasis and grade of differentiation, but no relation to clinicai stage. Conclusion The expressions of ICAM-3 and VEGF are related to radioresistance of cervical squamous cell carcinoma.

关 键 词：细胞间粘附分子-3血管内皮生长因子 宫颈鳞癌 放射治疗 免疫组化 

分 类 号：R758.630.3[医药卫生—皮肤病学与性病学]