运动、胸腺细胞凋亡与机制研究  

Mechanisms of the thymocyte apoptosis induced by exercise

作　　者：杨贵明[1] 王雪芹[2] 

机构地区：[1]中山大学南方学院,广东广州510000 [2]临沂大学,山东临沂276005

出　　处：《广州体育学院学报》2016年第4期97-100,共4页Journal of Guangzhou Sport University

摘　　要：主要通过文献资料法,对细胞凋亡的机制及运动与胸腺细胞凋亡的关系等进行了述评,其中细胞凋亡与死亡受体信号转导途径、细胞凋亡与线粒体凋亡途径和细胞凋亡与内质网凋亡途径是本文论述的重点。结果显示,有关胸腺细胞凋亡的死亡受体信号转导途径机制和线粒体机制研究不多,有关胸腺细胞凋亡的内质网机制甚少。现有研究显示运动诱导胸腺细胞凋亡与线粒体凋亡途径关系密切,其他有待进一步研究证实。Intense exercise leads to post- exercise lymphocytopenia and immunosuppression,possibly by triggering thymocyte apoptosis. This article reviews the death receptor,mitochondria and endoplasmic reticulum apoptosis mechanism,and tries to find the main mechanism of thymocyte apoptosis. Results： 1） The thymocyte apoptosis are mediated by death receptor and mitochondrial mechanisms; 2） The endoplasmic reticulum adjustment mechanism study is very little in thymus. These results suggest that exercise- induced thymocyte apoptosis relates to mitochondrial apoptotic mechanisms closely,and the other need to be confirmed by further studies.

关 键 词：运动 胸腺 凋亡 死亡受体 线粒体 内质网 

分 类 号：G804.2[文化科学—运动人体科学]