巨细胞病毒致儿童传染性单核细胞增多综合征81例临床分析  

Clinical study of cytomegalovirus-induced infectious mononucleosis-like syndrome in children

作　　者：洪淑君 潘静[1] 倪文泉 陈冶[1] 潘家华[1] 陈名武[1] 

机构地区：[1]安徽省立医院(安徽医科大学附属省立医院)儿科,安徽合肥230001

出　　处：《中华全科医学》2016年第10期1686-1688,1725,共4页Chinese Journal of General Practice

摘　　要：目的探讨巨细胞病毒引起的儿童传染性单核细胞增多综合征的临床特点。方法收集2010年1月-2014年12月在安徽省立医院住院部诊断为巨细胞病毒感染引起的传染性单核细胞增多综合征患儿的临床资料及实验室检查资料，共81例，进行回顾性分析。并与同期30例EB病毒感染引起的传染性单核细胞增多症患儿比较分析。结果81例巨细胞病毒引起的传染性单核增多综合征患儿（CMV组）年龄1～11岁，平均5．4岁，男女比例为1：0．84。临床表现为：发热、淋巴结肿大、咽峡炎、肝脾大、眼睑浮肿、喘息等。CMV组热程（9．15±4．65）d，与EB病毒引起的传染性单核细胞增多症患儿（EBV组）比较，差异无统计学意义（t=0．98，P〉0．05）；住院时间（15．88±4．31）d，与EBV组比较，差异有统计学意义（t=2．49，P〈0．05）；CMV组白细胞（16．85±6，33）×10^9／L、中性粒细胞数（4．19±2．84）×10^9／L、淋巴细胞数（12．50±6．03）×10^9／L，与EBV组比较，差异无统计学意义（t=1．16、1．08、1．44，P〉0．05）；CMV组血小板（260．46±80．69）×10^9／L及异型淋巴细胞升高程度，与EBV组比较差异有统计学意义（t=7．02、3．81，P〈0．001）。CMV组异性淋巴细胞数升高程度与住院时间存在相关性（F=82．79，P〈0．05）。结论巨细胞病毒致传染性单核细胞增多综合征的首发症状以发热最常见；与EB病毒感染者比较，其肝功能损害程度较轻，异型淋巴细胞升高程度较低、恢复至正常所需时间短，且异型淋巴细胞升高程度与住院时间有关。Objective To investigate the clinical features of cytomegalovirus-induced infectious mononucleosis-like syndrome in children. Methods We retrospectively reviewed the information of 81 children diagnosed with cytomegalovirus-induced infectious mononucleosis-like syndrome in our hospital between January,2010 and December, 2014, including their laboratory examine results and clinical data. The data were compared with 30 EB virus induced infectious mononucleosis children. Results A total number of 81 children with mononucleosis-like syndrome caused by CMV （ CMV group） , aged from 1 to 11 years with an average age of 5.4 years old, the male and female ratio was 1 ： 0.84, were enrolled into this study. The main clinical manifestations of the patients included fever,lymph node enlargement, angina, splenomegaly, palpebral edema,wheezing and so on. When compared with 30 EBV induced infectious mononucleosis children （ EBV group ） , the thermal process of CMV group was （ 9.15 ± 4.65 ） days, the difference between two groups was not statistically significant（ t = 0. 979 ,P 〉 0.05 ）. The length of patient stay in CMV group was （15.88 ±4.31 ） days, the difference between two groups was statistically significant（ t = 2. 492 ,P 〈 0. 001 ）. WBC of CMV group was （16.85 ± 6.33 ） ×10^9/L, the neutral granulocyte count of CMV group was （4. 19 ± 2.84） ×10^9/L, and the lymphocyte count was （12.50 ± 6.03）×10^9/L,the difference between two groups were not statistically significant （ t = 1. 16, t = 1.08, t = 1.44, P 〉 0.05）. The platelet count of CMV group was （260.46 ± 80.69）×10^9/L,the difference between two groups was statisti- cally significant （ t = 7.02, P 〈 0. 001 ）, as well as the degree of abnormal lymphocytes increased （ t = 3.814, P 〈 0. 001 ）. The increase of abnormal lymphocyte had relationship with the length of stay （ F = 82.79,P 〈 0.05 ）. Conclusion Fever is the most common clinical manifestations of cytomegalovirus-induced infectious mononucle

关 键 词：巨细胞病毒 传染性单核细胞增多综合征 EB病毒 

分 类 号：R725.127[医药卫生—儿科]