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作 者:吴秀继[1] 姚敏[1] 何启军[1] 余玲玲[2]
机构地区:[1]海口市人民医院检验科,海南海口570208 [2]温州医科大学附属第二医院检验科,浙江温州325000
出 处:《中华全科医学》2016年第10期1716-1718,共3页Chinese Journal of General Practice
基 金:2012年海南省卫生厅医学科研资助项目(琼卫2012PT-59);2012年海南省海口市重点科技计划项目(2013-54)
摘 要:目的探讨血清铁蛋白(SF)检测在2型糖尿病(T2DM)患者中的应用价值。方法选取2013年2月—2015年10月在海口市人民医院内分泌科就诊治疗的T2DM患者(T2DM组)120例,根据糖化血红蛋白(Hb A1c)水平分为:疗效良好组(A组)53例和疗效差组(B组)67例,同时选取正常健康人员(NC组)60例,测定血清铁(SI)、血清铁蛋白(SF)、转铁蛋白(TRF)、Hb A1c、空腹血糖(FPG)、空腹胰岛素(FINS)并计算胰岛素抵抗指数(HOMA-IR)与胰岛β细胞功能(HOMAβ-cell),比较T2DM组与NC组、A组与B组上述指标的变化,并分析其相关性。结果与NC组比较,T2DM组FPG、Hb A1c、FINS、HOMA-IR、SF均升高(P<0.05),而HOMAβ-cell降低(P<0.05);与A组比较,B组SF及HOMA-IR均升高(P<0.05),而HOMAβ-cell降低(P<0.05);T2DM患者SF与Hb A1c呈正相关(r=0.584,P<0.05)、与HOMA-IR呈正相关(r=0.451,P<0.05)、与HOMAβ-cell呈负相关(r=-0.468,P<0.05)。结论 T2DM患者体内铁代谢紊乱,铁超载可能加重胰岛素抵抗及β细胞的损坏;SF可能是影响其疗效的重要因素,SF高者血糖难控制。Objective To explore the application value of serum ferritin in the Type 2 diabetes mellitus (T2DM) patients. Methods Choose from February,2013 to October,2015 in Haikou City People' s Hospital of Endocrinology,diagnosis and treatment of patients with T2DM(T2DM group) 120 cases, according to glycated hemoglobin (HbAlc) levels are divided into :the efficacy of good group(A) and efficacy of 53 cases poor( group B ) 67 cases, while selecting normal controls( NC ) group, 60 cases. Serum iron ( SI ), serum ferritin ( SF ), transferring ( TRF ), glycosylated hemoglobin ( HbA1 c) , fasting plasma glucose (FPG) and fasting insulin ( FINS ) were determined and Calculated Insulin resistance index(HOMA-IR) and pancreatic β-cell function(HOMA β-cell) and compared the changes in T2DM group and NC group, group A and group B of the indicators and analysis of its relevance. Results Compared with the NC group,T2DM group FPG, HbA1 c, FINS, HOMA-IR and SF were increased ( P 〈 0.05 ) ; Compared with group A, SF SF and HOMA-IR of group B all increased( P 〈 0.05 ), HOMA β-cell decreased( P 〈 0.05 ) ;T2DM patients with SF and HbA1c were positively correlated ( r = 0. 584,P 〈 0. 05 ), positively correlated with HOMA-IR ( r = 0.451, P 〈 0.05 ) , and HOMA β-cell negative correlation( r = -0.468 ,P 〈 0.05 ). Conclusion T2DM patients with iron metabolism disorders, iron overload may increase insulin resistance and β cell damage;SF may be an important factor affecting its efficacy, high SF is difficult to control blood glucose.
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