呼吸道炎症无创检测技术在儿童支气管哮喘应用的研究进展  

Research progress in clinical application of noninvasive detection technology to respiratory inflammatory of bronchial asthma in children

作　　者：夏万敏[1] 刘瀚旻[1] 

机构地区：[1]四川大学华西第二医院,成都610041

出　　处：《中华妇幼临床医学杂志（电子版）》2016年第4期458-462,共5页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：国家自然科学基金项目(81401073)~~

摘　　要：儿童呼吸道炎症评估和监测,对于支气管哮喘的病情评价,治疗反应效果、预测急性发作和预后检测均具有重要意义。目前,对于呼吸道炎症检测相关技术,包括无创和有创二类。其中,呼吸道炎症无创检测技术,已成为哮喘管理的重要手段之一,主要包括呼吸道反应性测定、呼出气一氧化氮(FeNO)水平检测、诱导痰技术、血液与尿液白三烯(LT)水平检测,以及呼出气冷凝物(EBC)成分试验等。对呼吸道炎症无创检测技术和判定指标的标准化,是目前影响这些技术在儿童支气管哮喘临床应用的主要问题。It is essential to assess and monitor respiratory tract inflammation in asthmatic children patients for evaluating severity of bronchial asthma,treatment response and predicting acute exacerbation and outcome.Invasive and noninvasive techniques could be used in monitoring respiratory tract inflammation in asthmatic children patients.Noninvasive techniques have become one of the most important means for the management of asthma,including airway responsiveness detection,level of fractional concentration of exhaled nitric oxide（FeNO）detection,induced sputum detection,concentration of leukotrienes（LT）in blood and urine,and experiment for analysis of ingredients for exhaled breath condensate（EBC）.The decision criteria standardization of noninvasive detection technology to respiratory inflammatory of bronchial asthma in children will be the first step,and it is also the main problem that affects the clinical application of these techniques in children with asthma.

关 键 词：哮喘 呼吸困难 阵发性 支气管高反应性 呼吸道感染 呼吸道炎症 嗜酸性细胞 一氧化氮 白三烯 儿童 

分 类 号：R725.6[医药卫生—儿科]