泰州市新发现HIV/AIDS患者首次CD_4^+T淋巴细胞检测情况  

Analysis of initial CD_4^+ T lymphocyte counts of newly indentified HIV/ADIS Patients in Taizhou City

作　　者：魏爱旺[1] 于明润[1] 马智龙[1] 陆祥彬[1] 

机构地区：[1]江苏省泰州市疾病预防控制中心,泰州225300

出　　处：《江苏预防医学》2016年第4期400-402,共3页Jiangsu Journal of Preventive Medicine

摘　　要：目的了解泰州市新发现艾滋病病毒感染者/艾滋病患者(HIV/AIDS)患者首次CD4+T淋巴细胞水平,为艾滋病防治工作提供科学依据。方法对2014—2015年新发现HIV-1抗体确证阳性的HIV/AIDS病例进行随访;采集抗凝全血标本,以流式细胞术进行CD4+T淋巴细胞计数。结果共检测252例新发现HIV/AIDS病例,以男性(占84.52%)、<35岁(占41.27%)、已婚(占58.73%)、本地户籍(占67.86%)为主,感染途径主要为同性传播(占50.00%)和异性传播(占49.20%),样品主要来自其他就诊者(占36.11%)。首次CD4+T淋巴细胞计数均值为(387.67±266.97)/μL,其中≤500/μL的占70.63%;不同年龄组、婚姻状况、样品来源的HIV/AIDS首次CD4+T淋巴细胞计数差异均有统计学意义(P值均<0.05)。结论泰州市新发现HIV/AIDS首次CD4+T淋巴细胞免疫水平较低,发现较晚。应进一步扩大检测范围,做到早发现、早治疗、早控制,减少艾滋病的进一步传播、提高病例生存质量。Objectives To study initial CD- ＋ T lymphocytes counts of newly indentified HIV/AIDS Patients in Taizhou Cit- y; to provide scientific basis for ADIS disease control and prevention. Methods All newly identified HIV/AIDS patients from 2014 to 2015 were subjected to follow-up studies. Whole blood samples were collected for CD4 ＋T lymphocytes quantification by flow cytometry. Results A total of 252 newly discovered HIV/AIDS Patients were investigated, mainly were male （ 84.52%）, less than 35 years old （41.27%） and married （58.73%）,with local household registration （67.86%）. Homosexual transmission （50.00%） and heterosexual transmission （49.20%） were major transmission routes. Samples were collected mainly from other patients （36.11%）. The average of initial CD4 ＋ T lymphocyte counts was （387.67 ± 266.97 ） /μL, 70.63 of subjects were less than 500/μL. Initial CD＋ ＋ T counts of newly identified HIV/AIDS Patients were statistically different a- mong ages with different groups, marriage status or sample origins（all P〈0.05）. Conclusion The CD4 ＋ T lymphocyte level of HIV/AIDS patients was low; identification of HIV/AIDS Patients was late. Serological surveillance should be strengthened to achieve earlier diagnosis, treatment and control to reduce disease spreading and improve the living quality of patients.

关 键 词：HIV AIDS CD4+T淋巴细胞 

分 类 号：R512.91[医药卫生—内科学]