支气管哮喘患者呼出气一氧化氮与外周血嗜酸性粒细胞的相关性  

Correlation of exhaled nitric oxide with EOS in asthmatic patients

作　　者：王中新[1] 余红[1] 叶贤伟[1] 许梅[1] 吴瑞明[1] 陈仁华[1] 曾婷[1] 张湘燕[1] 

机构地区：[1]贵州省人民医院呼吸与危重症医学科,贵州贵阳550002

出　　处：《临床肺科杂志》2016年第9期1600-1602,共3页Journal of Clinical Pulmonary Medicine

摘　　要：目的 观察支气管哮喘患者呼出气一氧化氮（FeNO）的表达水平,分析其与外周血嗜酸性粒细胞（EOS）之间的相关性。方法 收集2013年2月-2014年12月期间贵州省人民医院支气管哮喘患者58例,其中支气管哮喘急性发作期40例（急性发作期组）,支气管哮喘缓解期18例（缓解期组）,健康对照组30例。采用FeNO分析仪测定FeNO水平,并检测各组外周血嗜酸粒细胞计数,采用SPSS 11.5统计软件进行统计学处理,组间差异性比较采用单因素方差分析,相关性分析采用Pearson相关性分析。P〈0.05为差异有统计学意义。结果 支气管哮喘急性发作期组FeNO为101.44±32.87ppb,EOS为5.0±2.62×10^9/L;缓解期组FeNO为32.83±11.42 ppb,EOS为1.32±0.59×10^9/L;健康对照组FeNO为8.43±3.02ppb,EOS为0.22±0.09×10^9/L。发作期组及缓解期组FeNO及EOS水平均高于健康对照组（P〈0.05）。急性发作期组与缓解期组比较,FeNO及EOS水平差异有统计学意义（P〈0.05）。支气管哮喘患者FeNO水平与EOS呈正相关性（P〈0.05）。结论 FeNO能够一定程度上反应气道嗜酸细胞炎症,FeNO检测可能有助于评估支气管哮喘的控制水平。Objective To analyze the level of exhaled nitric oxide （ FeNO） in asthmatic patients and its cor-relation with eosinophils （ EOS） .Methods Asthmatic patients and normal subjects from February 2013 to Decem-ber 2014 were enrolled in this investigation .The level of FeNO was detected in 40 asthmatic patients at exacerbation stage, 18 asthmatic patients at stable stage and 30 normal controls, respectively.EOS in all subjects were measured as well.It used SPSS11.5 to do statistical analysis of the experimental results , single factor variance to difference be-tween the two groups , and Pearson correlation test to correlation .Results The levels of FeNO and EOS were （101.44 ±32.87） ppb and （5.0 ±2.62 ×10^9/L） in the exacerbation group , （32.83 ±11.42） ppb and （1.32 ± 0.59 ×10^9/L） in the remission group, and （8.43 ±3.02） ppb and （0.22 ±0.09×10^9/L） in the control group. Furthermore, the expression levels of FeNO and EOS were obviously higher in the exacerbation group than in the re -mission group （P〈0.05）.FeNO was positively correlated with EOS in asthmatic patients （P〈0.05）.Conclusion FeNO can reflect asthma airway esinophilic inflammation levels , and it is a useful indicator of control in asthma.

关 键 词：支气管哮喘 气道炎症 一氧化氮 嗜酸性粒细胞 

分 类 号：R562.25[医药卫生—呼吸系统]