双嘧达莫联合阿司匹林、丙种球蛋白治疗川崎病的疗效及其对炎性因子的影响  

Effects of Dipyridamole,Aspirin and Gammaglobulin Therapy in Children with Kawasaki Disease and the Affection to the Levels of Inflammatory Factors

作　　者：焦爱萍[1] 秋艳萍[1] 黎建丽[1] 韩波[1] 刘银娜[1] 张孝兴[1] 

机构地区：[1]宝鸡市妇幼保健院,陕西宝鸡721000

出　　处：《儿科药学杂志》2016年第9期17-20,共4页Journal of Pediatric Pharmacy

摘　　要：目的:研究双嘧达莫联合阿司匹林、丙种球蛋白治疗川崎病的临床疗效及其对患儿降钙素原(PCT)、C反应蛋白(CRP)等炎性因子水平的影响。方法:将2011年5月至2015年5月在我院接受治疗的118例川崎病患儿作为研究对象,利用随机数表法分为观察组和对照组各59例。对照组患儿仅使用阿司匹林及丙种球蛋白治疗,观察组在对照组治疗基础上加用双嘧达莫治疗,观察两组患儿的临床疗效及发热、颈淋巴结肿胀、黏膜弥漫性充血、躯干红斑、结膜充血等症状缓解的时间;检测治疗后第1天、第3天、第6天、第9天、第12天及第15天两组患儿PCT及CRP变化情况;检测治疗第1天及第15天患儿其他炎性因子(TNF-α、IL-6、HMGB1及MIF)变化情况;观察两组患儿用药期间不良反应。结果:观察组患儿总有效率(96.61%)明显高于对照组(86.44%);观察组发热、颈淋巴结肿胀、黏膜弥漫性充血、躯干红斑及结膜充血等症状缓解的时间均明显短于对照组(P<0.05);观察组PCT及CRP水平改善程度分别于第9天后及第6天后优于对照组(P<0.05);治疗后其他炎性因子改善程度亦优于对照组(P<0.05)。结论:双嘧达莫联合阿司匹林和丙种球蛋白治疗川崎病具有较好的治疗效果,值得临床推广应用。Objective： To study the clinical efficacy of dipyridamole combined with aspirin and gammaglobulin on children with Kawasaki disease,and the affection to the levels of inflammatory factors. Methods： A total of 118 cases of children with Kawasaki disease from May 2011 to May 2015 in our hospital were randomly divided into observation group and control group. Control group only received gammaglobulin and aspirin treatment,the observe group further received dipyridamole. The effects and symptoms alleviating time in the two groups were observed. The levels of PCT and CRP in the two groups on the first,third,sixth,ninth,twelfth and fifteenth day were detected. The levels of the other inflammatory factors including TNF-α,IL-6,HMGB1 and MIF were detected on the first day and fifteenth day. The adverse reactions were observed in the two groups. Results： The total effective rate of observation group was96. 61%,which was higher than that in the control group（ 86.44%）（ P0.05）. Children with fever,mucosal congestion,neck lymph nodes dissipate and foot swelling time in the observe group were shorter compared with the control group（ P0.05）. The levels of PCT and CRP were significantly promoted after ninth days and sixth days（ P0.05）. The levels of TNF-α,IL-6,HMGB1 and MIF were also improved in the observation group（ P 0. 05）. There were no adverse reactions in the two groups. Conclusion： The use of dipyridamoledipyridamole combined with aspirin and gammaglobulin therapy in children with Kawasaki disease is better and it is worthy to perform the next work.

关 键 词：川崎病 双嘧达莫 阿司匹林 丙种球蛋白 炎性因子 

分 类 号：R725.6[医药卫生—儿科]