脑白质疏松伴认知障碍患者静息态功能磁共振成像研究  

Resting-state Functional Magnetic Resonance Imaging Study of Leukoaraiosis Patients with Cognitive Impairment

作　　者：沈慧聪[1] 常天静 詹炯[1] 李越秀[3] 张玉梅[3] 张宁[4,5] 王春雪[4,5] 马军[1] 

机构地区：[1]首都医科大学附属北京天坛医院放射科,北京100050 [2]北京大学首钢医院放射科 [3]首都医科大学附属北京天坛医院神经内科 [4]首都医科大学附属北京天坛医院国家神经系统疾病临床研究中心 [5]神经精神医学与临床心理科

出　　处：《中国卒中杂志》2016年第7期530-535,共6页Chinese Journal of Stroke

基　　金：首都临床特色应用研究(Z151100004015127);北京市自然科学基金(7092027)

摘　　要：目的研究脑白质疏松(leukoaraiosis,LA)伴发认知障碍患者与健康人静息态脑网络的差异。方法分别对根据影像学及临床确诊的40例脑白质疏松伴认知障碍患者及30例年龄、性别、受教育程度均匹配的健康对照者进行静息态功能磁共振扫描,采用独立成分分析法得到两组被试者的激活区,对两组数据进行比较,得到两组间的激活差异区。结果脑白质疏松伴认知障碍患者默认网络中双侧楔前叶、左侧颞下回、左侧枕颞内侧回、右侧前扣带回激活较正常对照组减弱,左侧中央旁小叶及右侧楔叶激活程度较正常对照组增强。结论脑白质疏松伴认知障碍患者与健康人在脑静息网络激活程度上存在差异。Objective To investigate the differences in the resting state network between patients with cognitive impairment related leukoaraiosis and normal control.Methods A total of 40 patients with leukoaraiosis related cognitive impairment diagnosed by iconographic and clinical diagnosis and 30 normal controls were included in this study. The restingstate functional magnetic resonance imaging was scanned. All subjects of the two groups were matched in age, gender and level of education. The independent component analysis was used to deal with the data, and the two-sample t-test was used to compare the differences between the two groups.Results Compared with the normal control group, leukoaraiosis patients with cognitive impairment showed significantly decreased activation at bilateral precuneus, left inferior temporal gyrus, left fusiform gyrus and right anterior cingulate; increased activation at left paracentral lobule and right cuneus; significantly increased activation at left superior temporal gyrus; and significantly decreased activation at bilateral cuneus, middle occipital gyrus and left lingual gyrus.Conclusion There were many differences in resting-state functional brain network between patients with cognitive impairment related leukoaraiosis and normal control.

关 键 词：脑白质疏松 认知障碍 静息态功能磁共振 静息态网络 

分 类 号：R445.2[医药卫生—影像医学与核医学] R741[医药卫生—诊断学]