α,β-不饱和羰基化合物的不对称Diels-Alder反应研究进展  

Progress on the Asymmetric Diels-Alder Reaction of α,β-Unsaturated Carbonyl Compounds

作　　者：刘文香[1,2] 吴宇强[1,2] 李灵芝[2,3] 李霞[2,3] 

机构地区：[1]天津医科大学药学院,天津300070 [2]武警后勤学院药物化学教研室,天津300309 [3]天津市职业与环境危害防制重点实验室,天津300309

出　　处：《有机化学》2016年第7期1501-1512,共12页Chinese Journal of Organic Chemistry

基　　金：武警后勤学院博士启动基金(No.WHB201506)和武警后勤学院创新团队科学基金(No.WHTD201303)资助项目~~

摘　　要：Diels-Alder反应是典型的[4+2]环合反应,自被发现以来备受化学家们的重视.不对称Diels-Alder反应是合成手性中间体的有效手段,在手性药物和天然产物全合成中得到广泛应用.α,β-不饱和羰基化合物是有机合成反应的关键中间体,根据其结构特点和催化体系类型,分类阐述了α,β-不饱和羰基化合物为亲双烯体的不对称正电子需求Diels-Alder反应的研究进展.Diels-Alder reaction is a [4＋2] concerted cycloaddition reaction, which has attracted considerable attention since its discovery. Asymmetric Diels-Alder reaction is an effective method for synthesis of chiral intermediates, so it was widely applied in the total synthesis of drugs and natural products, α,β-Unsaturated carbonyl compounds are a kind of highly reactive versatile intermediates in organic synthesis, according to its structural characteristics and catalytic types, recent advances in asymmetric normal electron-demand Diels-Alder reaction of α,β-unsaturated carbonyl compounds are reviewed in this paper.

关 键 词：不对称Diels—Alder反应 天然产物 有机合成反应 Α Β-不饱和羰基化合物 

分 类 号：O621.251[理学—有机化学]