中国福建畲族自然人群血管结构功能及其影响因素  

Vascular function and structure and related influencing factors in Fujian She nationality Chinese

作　　者：洪永强[1] 刘欢[2] 吴秀琴[1] 张晓滨[1] 黄孟华[1] 王靖 王宏宇[2] 

机构地区：[1]福建医科大学附属闽东医院超声医学科,福建宁德355000 [2]北京大学首钢医院血管医学科,北京100144

出　　处：《中国医学影像技术》2016年第8期1200-1204,共5页Chinese Journal of Medical Imaging Technology

基　　金：卫生部十年百项计划项目(04-10-01);2014年福建省医学创新课题(2014-CXB-25)

摘　　要：目的探讨中国福建畲族自然人群血管结构功能及其影响因素。方法选取358名福建畲族志愿者,根据颈-股动脉脉搏波传导速度(cf-PWV)不同分为动脉弹性正常组(cf-PWV≤9m/s,144名)和动脉弹性降低组(cf-PWV>9m/s,214名)。应用多普勒超声诊断仪测定左侧颈动脉内膜-中层厚度(L-CIMT)、右侧颈动脉内膜-中层厚度(R-CIMT),并进行实验室检查测定总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、空腹血糖(FPG)、尿酸(UA)、尿素氮(BUN)、肌酐(Cr)、超敏C反应蛋白。并进行统计学分析。结果动脉弹性降低组的L-CIMT、R-CIMT、年龄、心率、收缩压、舒张压、脉压、BUN、Cr、FPG、TG、TC、cf-PWV、LDL-C水平均显著高于动脉弹性正常组(P均<0.05)。动脉硬化的危险因素包括年龄、心率、收缩压、BUN、TC,而LDL-C是动脉硬化的保护因素。动脉弹性降低组和动脉弹性正常组cf-PWV与L-CIMT、R-CIMT均呈正相关(r=0.369、0.316,0.223、0.171,P均<0.05)。L-CIMT的独立影响因素为年龄和收缩压(P均<0.05),R-CIMT的独立影响因素为年龄和脉压(P均<0.05)。结论中国福建畲族自然人群的年龄、心率、收缩压、BUN、TC是动脉硬化的危险因素,cf-PWV与双侧CIMT均呈正相关。Objective To investigate vascular function and structure and related influencing factors in Fujian She national- ity Chinese. Methods A total of 358 Fujian She nationality volunteers were collected. According to the carotid femoral pulse wave velocity （cf-PWV） values, the volunteers were divided into two groups： Normal arterial elasticity group （cf- PWV≤9 m/s, n= 144） and arterial elasticity decreased group （cf-PWV〉9 m/s, n： 214）. They all underwent detection of left carotid intima media thickness （L-CIMT）, right carotid intima media thickness （R-CIMT）, and laboratory examination such as total cholesterol （TC）, high density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL- C）, triglyceride （TG）, fasting plasma glucose （FPG）, uric acid （UA）, urea nitrogen （BUN）, creatinine （Cr） and high sensitive C reactive protein. The indexes were statistically analyzed. Results L-CIMT, R-CIMT, age, heart rate, systolic blood pressure, diastolic blood pressure, pulse pressure, BUN, Cr, FPG, TG, TC, cf-PWV, LDL-C were significantly higher in arterial elasticity decreased group than those in normal arterial elasticity group （all P〈0.05）. Age, heart rate, systolic blood pressure, BUN and TC were risk factors of arterial stiffness, and LDL-C was protecting factor. The cf-PWV was positively correlated with both of L-CIMT and R-CIMT in arterial elasticity decreased group and normal arterial elastic ity group （r=0. 369, 0. 316 and r=0. 223, 0. 171, all P〈0.05）. Age and systolic blood pressure were independent influ- encing factors of L-CIMT （both P〈0.05）, and age and pulse pressure were independent influencing factors of R-CIMT （both P〈0.05）. Conclusion Age, heart rate, systolic blood pressure, BUN, and TC are risk factors of arterial stiffness in Fujian She nationality Chinese. In addition, cf-PWV were both positively correlated with L-CIMT and R-CIMT.

关 键 词：畲族 脉搏波传导速度 动脉僵硬度 颈动脉 内-中膜厚度 超声检查 

分 类 号：R543[医药卫生—心血管疾病] R445.11[医药卫生—内科学]