脑梗死患者肺部感染血清质金属蛋白-9及肿瘤坏死因子-α水平的分析  

MMP-9and TNF-αlevels after pulmonary infection in patients with carotid artery atherosclerotic cerebral infarction

作　　者：田龙[1] 任军[1] 胡浩[1] 丁娜[1] 白金娟[1] 

机构地区：[1]郑州人民医院神经内科,河南郑州450003

出　　处：《中华医院感染学杂志》2016年第15期3425-3427,共3页Chinese Journal of Nosocomiology

基　　金：河南省卫生厅重点基金资助项目(20110329)

摘　　要：目的探讨肺部感染对颈动脉粥样硬化性脑梗死患者血清基质金属蛋白9(MMP)-9及肿瘤坏死因子a(TNF)-α水平的影响,为临床研究提供参考依据。方法选择2012年1月-2015年8月120例诊断为颈动脉粥样硬化性脑梗死患者作为研究对象,根据住院期间是否发生肺部感染分为感染组24例与非感染组96例;所有患者均于治疗前、感染后及感染控制后3d采集静脉血,检测MMP-9和TNF-α水平,分析肺部感染对其影响。结果感染组患者发生感染后MMP-9水平为(751.84±98.74)pg/ml,明显高于入院时(240.42±72.64)pg/ml及同期未感染组患者(246.22±71.02)pg/ml;感染组发生感染后TNF-α水平为(4.84±0.79)ng/ml,明显高于入院时(1.22±0.42)ng/ml及同期未感染组患者(1.32±0.45)ng/ml,差异均有统计学意义(P<0.05)。结论颈动脉粥样硬化性脑梗死患者肺部感染后血清MMP-9及TNF-α水平明显升高,感染控制后降低,因此有助于临床肺部感染的早期识别及预后评估。OBJECTIVE To analyze the effect of MMP-9and TNF-αafter pulmonary infection in patients with carotid artery atherosclerotic cerebral infarction,so as to provide references for clinical researches.METHODS A total of 120 patients with carotid artery atherosclerotic cerebral infarction from Jan.2012 to Aug.2015 were selected,and divided into infection group and non-infection group according to whether occurring pulmonary infection.The levels of MMP-9and TNF-α were detected before treatment,after infection and 3dafter infection control.RESULTS The level of MMP-9was（751.84±98.74）pg/ml after pulmonary infection in infection group,which was higher than（240.42±72.64）pg/ml of admission and（246.22±71.02）pg/ml of the same period in non-infection group.The level of TNF-αwas（4.84±0.79）ng/ml after pulmonary infection in infection group,which was higher than（1.22±0.42）ng/ml of admission and（1.32±0.45）ng/ml of the same period in non-infection group（P〈0.05）.The level of MMP-9reduced to（2.52±0.54）ng/ml in infection group after infection control3 d,which were higher than（1.30±0.51）ng/ml same period in non-infection group（P〈0.05）.The levels of MMP-9and TNF-αwere（784.51±71.61）pg/ml and（4.95±0.89）ng/ml after pulmonary infection in patients with plaque formation,which were higher than（714.46±61.27）pg/ml,（4.41±0.73）pg/ml in patients with intima-media thickness（P〈0.05）.CONCLUSION The levels of MMP-9and TNF-αincreased significantly after pulmonary infection in patients with carotid artery atherosclerotic cerebral infarction,but reduced after infection control,so it will help to early identification and prognosis evaluation of clinical pulmonary infectio.

关 键 词：肺部感染 基质金属蛋白 肿瘤坏死因子 

分 类 号：R563.1[医药卫生—呼吸系统]