糖尿病患者尿道感染血清与尿液氧化应激指标的变化观察  

Changes of serum and urine oxidative stress indexes of patients with diabetes combined with urinary tract infection

作　　者：吴强鹏[1] 王利玲[2] 沈丽新[1] 刘朝仁[1] 魏莱[1] 侯君[1] 

机构地区：[1]攀枝花市中西医结合医院内分泌科,四川攀枝花617000 [2]攀枝花市中西医结合医院呼吸科,四川攀枝花617000

出　　处：《中华医院感染学杂志》2016年第15期3436-3438,共3页Chinese Journal of Nosocomiology

基　　金：四川省科技厅科技攻关基金资助项目(2012009879XX)

摘　　要：目的观察糖尿病合并尿道感染患者血清与尿液氧化应激指标的变化情况,以为其干预措施的制定提供参考依据。方法选取2014年6月-2015年11月医院收治54例糖尿病合并尿道感染患者为A组,54例糖尿病无尿道感染患者为B组,54例单纯尿路感染患者为C组,54名健康人员为D组,比较4组血清及尿液氧化应激指标,数据采用SAS 6.0软件进行统计分析。结果 A组患者血清及尿液活性氧及褪黑素水平分别为(72.31±5.80)nU/ml、(45.68±5.20)ng/L及(63.74±4.98)nU/ml、(35.28±4.37a)ng/L,均低于其他3组,B组及C组则低于D组,差异均有统计学意义(P<0.05);A组不同糖化血红蛋白水平患者血清及尿液SOD、MT水平分别低于B组,MDA则高于B组,差异均有统计学意义(P<0.05);A组不同感染部位患者血清及尿液SOD及MT水平分别低于C组,MDA则高于C组,差异均有统计学意义(P<0.05)。结论糖尿病合并尿道感染患者血清与尿液氧化应激指标的变化较大,且糖化血红蛋白水平及感染部位对血清及尿液上述指标影响均较大。OBJECTIVE To observe the change situation of serum and urine oxidative stress indexes of patients with diabetes combined with urinary tract infection,in order to provide reference for the intervention measure.METHODS A total of 54 patients with diabetes combined with urinary tract infection in hospital from Jun.2014 to Nov.2015 were selected as the group A,another 54 patients with patients with diabetes and without infection as the group B,another 54 patients with urinary tract infection only as the group C,another 54 healthy persons as the group D,then the serum and urine oxidative stress indexes of four groups were compared.SAS 6.0was used for the data analysis.RESULTS The serum and urine reactive oxygen and melatonin in group A were respectively（72.31±5.80）nU/ml,（45.68±5.20）ng/L and（63.74±4.98）nU/ml,（35.28±4.37a）ng/L,and they were all lower than the other three groups,group B and C lower than group D,and the differences were all significant（P〈0.05）;The serum and urine MDA and MT levels of group A with different glycated hemoglobin levels were lower than those in group B,but MDA was higher than group B（P〈0.05）.The serum and urine SOD and MT levels in group A different infection sites patients were lower than group C,but MDA was higher than group C（P〈0.05）.CONCLUSIONThe change of serum and urine oxidative stress indexes of patients with diabetes combined with urinary tract infection are greater,and the influence of glycosylated hemoglobins and infection sites for the serum and urine indexes are both greater too.

关 键 词：糖尿病 尿道感染 血清 尿液 氧化应激指标 

分 类 号：R691.3[医药卫生—泌尿科学]