非甾体抗炎药致上消化道出血的临床特征分析  

Analysis on clinical characteristics of upper gastrointestinal bleeding induced by NSAIDs

作　　者：庄俊雪 潘霖[2] 

机构地区：[1]天津市宝坻区人民医院,天津301800 [2]天津市第一中心医院,天津300192

出　　处：《现代药物与临床》2016年第7期1107-1109,共3页Drugs & Clinic

摘　　要：目的分析非甾体抗炎药致上消化道出血的临床特征。方法选取天津市第一中心医院2012年10月—2015年6月消化道出血的住院患者110例,对其临床资料进行分析统计。按照出血前10 d内是否服用过非甾体抗炎药为标准对患者进行分组,比较两组的临床特征。结果两组患者在急性胃黏膜病变、胃底和胃窦胃溃疡、心血管病史以及前壁和后壁十二指肠溃疡方面存在显著差异,两组比较具有统计学意义(P<0.05)。其中用药组的急性胃黏膜病变、胃底和胃窦胃溃疡、心血管病史所占比例大于非用药组,而用药组的前壁和后壁十二指肠溃疡所占比例小于非用药组。结论在临床治疗过程中,需要采取适当的措施有效地降低非甾体抗炎药所致的上消化道出血等不良反应。Objective To analyze the clinical characteristics of upper gastrointestinal bleeding induced by NSAIDs. Methods Inpatients（110 cases） with upper gastrointestinal bleeding in Tianjin First Center Hospital from November 2012 to June 2015 were selected, and the clinical data were retrospectively analyzed. The patients were divided into two groups according to the criterion whether taking NSAIDs in 10 d before bleeding, and the clinical characteristics between two groups were compared. Results There were significant difference in acute gastric mucosal lesion, gastric ulcer of fundus and antrum, a history of cardiovascular disease, and duodenal ulcer of antetheca and backwall between two groups（P〈0.05）. The proportion of acute gastric mucosal lesion, gastric ulcer of fundus, and antrum, and a history of cardiovascular disease in the drug group was higher than that in non-drug group. While the proportion of duodenal ulcer of antetheca and backwall was lower than that in non-drug group. Conclusion Some actions should be taken to reduce adverse reactions such as upper gastrointestinal bleeding induced by NSAIDs in the treatment progress.

关 键 词：非甾体抗炎药 上消化道出血 临床特征 

分 类 号：R975[医药卫生—药品]