新疆克拉玛依市健康人群乙肝抗体水平及感染状况  

Antibody level and infection status of hepatitis B among healthy people in Karamay City of Xinjiang

作　　者：黄玉莲[1] 李君梅[1] 陈园生[2] 李淑华[1] 

机构地区：[1]克拉玛依市疾病预防控制中心,新疆克拉玛依834000 [2]中国疾病预防控制中心,北京100050

出　　处：《职业与健康》2016年第14期1933-1935,1939,共4页Occupation and Health

基　　金：新疆维吾尔自治区科学技术支撑项目(201233141);克拉玛依市科技项目(SK2014-54)

摘　　要：目的了解克拉玛依市健康人群乙型肝炎（乙肝）抗体水平,为防控乙肝提供参考依据。方法按照随机抽样方法,采集0~60岁健康人群1 056人份血样,应用酶联免疫吸附试验（ELISA）法定量检测乙肝表面抗体（抗-HBs）、乙肝核心抗体（抗-HBc）;定性检测乙肝表面抗原（HBs Ag）。结果检测1 056人,人群HBs Ag阳性率为1.99%,抗-HBc阳性率为14.30%,抗-HBs阳性率为79.17%,抗-HBs几何平均浓度（GMC）为159.90 m U/ml;乙肝病毒（HBV）感染率为14.49%。15岁以下儿童HBs Ag阳性率为0.16%,抗-HBs平均阳性率为80.65%,HBV感染率为3.27%。结论该市人群乙肝流行特征发生改变,15岁以下儿童HBs Ag阳性率、HBV感染率下降明显。25岁以上成人感染率高,今后应加大成人乙肝防治的宣传,提高人群乙肝疫苗接种率。[Objective]To understand the antibody level of hepatitis B among healthy people in Karamay City,provide reference basis for prevention and control of hepatitis B. [Methods]1 056 blood samples were collected from healthy people aged 0-60 years old according to the random sampling method. ELISA was applied to quantitatively detect the anti-HBs and anti-HBc,and qualitatively detect the HBs Ag. [Results]Among 1 056 detected people,the positive rate of HBs Ag was 1.99%,the positive rate of anti-HBc and anti-HBs was 14.30% and 79.17% respectively,the geometric mean concentration（GMC） of anti-HBs was159.90 m U/ml,and the infection of HBV was 14.49%. The positive rate of HBs Ag in children under 15 years old was 0.16%,the average positive rate of anti-HBs was 80.65%,and the infection of HBV was 3.27%. [Conclusion]The epidemic characteristics of hepatitis B in Karamay City have changed： the positive rate of HBs Ag and infection rate of HBV in children under 15 years old have decreased significantly. The infection rate in people above 25 years old is high. Therefore,it is necessary to strengthen the publicity of hepatitis B prevention and treatment in adults and improve the hepatitis B vaccination rate.

关 键 词：乙型肝炎 乙型肝炎疫苗 HBS AG 抗-HBS 

分 类 号：R181.3[医药卫生—流行病学]