丙戊酸钠联合左乙拉西坦治疗小儿癫痫的疗效及安全性  

Efficacy of Sodium Valproate Combined with Levetiracetam in Treatment of Children with Epilepsy

作　　者：麦少珍 何敬成[2] 杜斌 

机构地区：[1]佛山市顺德区伍仲珮纪念医院药械科,广东佛山528300 [2]佛山市顺德区第一人民医院药剂科,广东佛山528300

出　　处：《中国医院用药评价与分析》2016年第7期908-910,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:探讨丙戊酸钠联合左乙拉西坦小儿癫痫的疗效及安全性。方法:选取2014年2月—2015年2月收治的82例癫痫患儿,按随机数字表法分为对照组41例和观察组41例。对照组患儿给予丙戊酸钠联合托吡酯,观察组患儿给予丙戊酸钠联合左乙拉西坦,观察2组患儿的疗效、相关实验室指标及不良反应发生情况。结果:治疗后,观察组患儿的总有效率为95.12%(39/41),明显高于对照组的80.49%(33/41),差异有统计学意义(P<0.05);2组患儿血钙、血磷水平均较治疗前降低,且观察组改善情况优于对照组,差异有统计学意义(P<0.05);2组患儿均未见严重不良反应发生。结论:丙戊酸钠联合左乙拉西坦治疗小儿癫痫的疗效显著,可明显改善患儿症状,安全性较高,在临床中具有良好的应用价值。OBJECTIVE： To probe into the clinical efficacy and safety of sodium valproate combined with levetiracetam in treatment of children with epilepsy. METHODS： 82 children with epilepsy admitted from Feb. 2014 to Feb. 2015 were selected to be divided into observation group and control group via the random number table,with 41 cases in each. The control group were treated with sodium valproate combined with topiramate, while the observation group received sodium valproate combined with levetiracetam. The efficacy,relevant laboratory indicators and adverse drug reactions of two groups were observed. RESULTS： After treatment,the total effective rate of observation group was 95. 12%（ 39 /41）,significantly higher than that of control group [80. 49%（ 33 /41） ],with statistically significant difference（ P〈0. 05）. Compared with before treatment,the levels of blood calcium and phosphorus after treatment significantly decreased,the improvement of various indicators in observation group were better than that in control group,with statistically significant difference（ P〈0. 05）. There was no severe adverse drug reactions occurred in two groups. CONCLUSIONS： The efficacy of sodium valproate combined with levetiracetam in treatment of children with epilepsy is remarkable,which can improve the symptoms in children with epilepsy with high safety. Thus it has good application value in clinic.

关 键 词：癫痫 丙戊酸钠 左乙拉西坦 托吡酯 

分 类 号：R971[医药卫生—药品] R985[医药卫生—药学]