短效与长效硝苯地平治疗妊娠高血压的临床效果对比分析  

Clinical effect of short acting and long-acting nifedipine in the treatment of pregnancy induced hypertension

作　　者：杨海燕[1] 

机构地区：[1]四川省达州市妇幼保健院药剂科,四川达州635000

出　　处：《医药前沿》2016年第22期26-27,共2页Journal of Frontiers of Medicine

摘　　要：目的：对比短效与长效硝苯地平治疗妊娠高血压的临床效果。方法：从我院诊疗的妊娠高血压患者中筛选出98例，依据随机分配原则将其分为对照组与研究组，各49例，分别采用短效硝苯地平、长效硝苯地平治疗，完成为期1w的治疗后观察患者的血压变化情况，同时观察产妇分娩方式及母婴结局等的差异。结果：两组患者治疗前SBP、DBP无明显差异（P〉0．05），两组治疗后血压均降低（P〈0．05），但研究组的血压控制效果更为理想（P〈0．05）；研究组的自然分娩率明显高于对照组（P〈O．05），产妇胎盘早剥、产后出血、胎儿宫内窘迫及死亡等的发生率与对照组相比均明显更低（P〈0．05）。结论：针对妊娠高血压给予长效硝苯地平降压效果更为显著，且有助于减少母婴不良结局的发生，推荐作为临床治疗的首选药物。Objective A comparative study of clinical effect of short acting and long-acting nifedipine treatment of hypertension in pregnant. Methods From our hospital diagnosis and treatment of patients with pregnancy induced hypertension screened 98 cases, according to the principle of random assignment will be the as control group and the study group （49 cases）, respectively, using short acting nifedipine and nifedipine treatment, observation of blood pressure change in patients after the completion of the period of 1W treatment, and to observe the differences in maternal mode of delivery and maternal and neonatal outcomes. Results Treatment of SBP, DBP, no significant difference （P 〉 0.05） were compared between the two groups of patients, blood pressure compared before and after treatment in each group were able to decreased （P 〈 0.05）, the blood pressure in study group compared to the control effect is more precise （P 〈 0.05）; study group of natural birth rate was significantly higher than the control group （P 〈 0.05）, and from the maternal and neonatal outcomes, maternal placental abruption, postpartum hemorrhage, fetal distress and death incidence and control group compared were significantly lower （P 〈 0.05）. Conclusion The pregnancy induced hypertension treated with long-acting nifedipine treatment for antihypertensive effect is more significant, and contribute to to reduce the occurrence of adverse maternal outcomes, recommended as the drug of choice for clinical treatment.

关 键 词：短效 长效 硝苯地平 妊娠高血压 

分 类 号：R544.1[医药卫生—心血管疾病]