左炔诺孕酮宫内节育系统治疗子宫腺肌病患者的疗效及对相关激素水平的影响  

The effect of Levonorgestrel Intrauterine System treatment of adenomyosis and related hormones

作　　者：张春艳[1] 王晓娟[1] 邵雷[1] 朱秀波[1] 王红娇[1] 夏庆玲[1] 

机构地区：[1]齐齐哈尔医学院附属第二医院,黑龙江齐齐哈尔161000

出　　处：《中外女性健康研究》2016年第12期1-2,4,共3页Women＇s Health Research

基　　金：左炔诺孕酮宫内节育系统治疗子宫腺肌病的临床观察;项目来源:齐齐哈尔市科学技术局(项目编号:SFZD-2014051)

摘　　要：目的:观察左炔诺孕酮宫内节育系统对子宫腺肌病患者的疗效及相关激素水平的影响。方法:选择本院于2013年3月至2014年5月收治的子宫腺肌病患者80例作为研究对象,均放置左炔诺孕酮宫内节育系统,于治疗前和治疗后的3、6、12个月测定月经第3d血清FSH、LH、E_2水平,并采取免疫组化链霉菌抗生素蛋白-过氧化酶连接法测定患者子宫内膜中ER、PR表达水平,进行统计学分析。结果:放置左炔诺孕酮宫内节育系统后,患者PBAC评分及VRS评分均显著降低,差异具有统计学意义,均P<0.05。放置前后血清FSH、LH、E_2水平比较无显著统计学差异,均P>0.05。患者子宫内膜中ER在放置6个月、12个月后分别为0.8±0.3、0.7±0.4,均低于放置前的1.8±0.6,PR表达水平在放置6个月、12个月后分别为0.7±0.3、0.5±0.4,均低于放置前的1.7±0.7,差异具有统计学意义,均P<0.05。结论:左炔诺孕酮宫内节育系统可有效缓解子宫腺肌病患者痛经、月经量过多,且对患者卵巢功能无明显影响。Objective： To observe the effect of Levonorgestrel Intrauterine System treatment of adenomyosis and related hormones. Methods： 80 cases of patients with adenomyosis treated in our hospital from March 2013 to May 2014 as the research objects, all were placed levonorgestrel releasing intrauterine system. Before treatment and after 3 months, 6 months, 12 months of treatmentserum FSH, LH, E2 level was detected by electro chemiluminescence immunoassay. The expression of ER and PR in endometrium of patients immunohistochemica was determined by Streptomyces avidin peroxidase connection method. The relevant data of before and after treatment were comparedto statistically analyze. Results： After levonorgestrel releasing intrauterine system, patients＇ PBAC score and VRS scores reduced significantly, and the difference was statistically significant,P〈 0. 05. There was no significant difference in serum FSH, LH and Fe before and after the placement, P 〉 0. 05. After 6 months, 12 months, patients＇ ER were 0. 8±0. 3.0. 7±0. 4,and were lower thanl. 84-0. 6）of before treatment , and the ex- pression level of PR after 6 months and 12 months respectively were 0. 7±0. 3.0. 5±0. 4, and lower than 1.7±0. 7 of before treatment, and the difference was statistically significant （P 〈 0. 05）. Conclusion： Levonorgestrel releasing intrauterine system can effectively alleviate the uterus adenomyosis patients with dysmenorrhea, menstrual quantity too much, and the ovarian function of patients has no significant effect.

关 键 词：左炔诺孕酮 宫内节育系统 卵巢功能 子宫腺肌病 

分 类 号：R711.71[医药卫生—妇产科学]