蒿甲醚结肠定位微丸的制备及体外释放度评价  

Study on the Preparation of Artemether Colon-specific Pellets and the Release in Vitro

作　　者：马寅 张伟 张国丽 张锐武 杨兆祥 

机构地区：[1]大理大学,云南大理671000 [2]昆药集团股份有限公司,昆明650106

出　　处：《大理大学学报》2016年第8期8-10,共3页Journal of Dali University

摘　　要：目的:拟制备蒿甲醚pH依赖型结肠定位微丸,并对其体外释放度进行考察。方法:采用挤出滚圆法制备丸芯,采用Eudragit S100作为包衣材料,柠檬酸三乙酯作为增塑剂,使用流化床包衣设备进行包衣。结果:在pH 1.2溶液2 h中未检测到蒿甲醚;在pH 6.8磷酸盐缓冲液中4 h累积释放度均小于5%;而在pH 7.6磷酸盐缓冲液中,3 h累积释放度均达90%以上。结论:本方法制备的蒿甲醚结肠定位微丸能达到结肠定位释药的目的。Objective： To prepare Artemether colon-specific pellets controlled by pH and study the release in vitro. Methods： Thecores of pellets were made by extrusion-spheronization. Pellets were prepared using a fluid bed coater , with Eudragit S100 as the outlayer, triethyl citrate added to the dispersion as the plasticizer. Results： Artemether was not detected in solution of pH 1.2 for 2 h. Theaccumulative release in pH 6.8 phosphate buffer for 4 h was smaller than 5%. While the accumulative release in the pH 7.6 phosphatebuffer for 3 h was more than 90%. Conclusion： Colon-specificpellets prepared in this way can well perform colon-specific delivery.

关 键 词：蒿甲醚 PH依赖型 结肠定位 体外释放度 

分 类 号：R944[医药卫生—药剂学]