血红素氧化酶-2、促肾上腺皮质激素释放激素在早发型重度子痫前期胎盘组织中的表达  

Expressions of HO-2 and CRH in placentas of severe preeclampsia

作　　者：伦巍巍[1] 朱建坡[1] 张曦[1] 程国梅[1] 任琛琛[1] 黄彦霞[1] 

机构地区：[1]郑州大学第三附属医院妇产科,450052

出　　处：《中国实用医刊》2016年第15期36-38,F0004,共4页Chinese Journal of Practical Medicine

摘　　要：目的：研究早发型重度子痫前期（ES-PE）患者胎盘组织中血红素氧化酶-2（HO-2）、促肾上腺皮质激素释放激素（ CRH）的表达，探讨其在重度子痫前期发病机制中的作用。方法选择早发型重度子痫前期患者25例为ES-PE组，正常妊娠者25例（对照组）进行实验对照研究，应用免疫组化方法研究HO-2、CRH的表达情况。结果 ES-PE组胎盘中HO-2的表达明显低于对照组，差异有统计学意义（P﹤0.05）。CRH在ES-PE组胎盘中的表达升高，与对照组比较差异有统计学意义（P﹤0.05）。结论胎盘中CRH的表达增加、HO-2表达的降低可能与重度子痫前期的发病有关。Objective To investigate the expression of HO-2 and CRH in placenta of severe pre-eclampsia,and to investigate the further etiology and pathogenesis of severe preeclampsia. Methods A case-control study was carried out on 25 cases of severe early-onset preeclampsia（ ES-PE group）and 25 cases of normal pregnancy（ control group）. Using immunohistochemistry to analyze the expression of pla-centa HO-2 and CRH. Results The expression of HO-2 in ES-PE group was significantly lower than that of the control group（ P﹤0. 05 ）. The expression of CRH in ES-PE group was significantly higher than that of the control group（ P﹤0. 05 ）. Conclusions The elevated expressions of CRH and the lower ex-pressions of HO-2 may have relationship with the genesis of severe early-onset preeclampsia.

关 键 词：早发型重度子痫前期 病因学 血红素氧化酶-2 促肾上腺皮质激素释放激素 胎盘 

分 类 号：R714.21[医药卫生—妇产科学]