线粒体偶联因子-6(CF6)与冠心病患者支架植入后内膜增生程度的关系  

Study about the Effect of Mitochondrial Coupling Factor-6(CF6) on Intimal Proliferation of Coronary Heart Disease Patients after Stent Implantation

作　　者：张晓元[1] 杨光[1] 罗文婷[1] 曹培刚 杨爽[1] 

机构地区：[1]哈尔滨医科大学附属第二医院,黑龙江哈尔滨150086 [2]王岗农垦总局医院,黑龙江哈尔滨150086

出　　处：《现代生物医学进展》2016年第23期4450-4453,4501,共5页Progress in Modern Biomedicine

基　　金：黑龙江省自然科学基金面上项目(D201206)

摘　　要：目的:研究冠心病不稳定型心绞痛患者支架植入术后CF6浓度变化与支架内膜增生程度的关系。方法:筛选符合入组条件的患者20例,入组患者于造影前、造影后即刻、支架植入术(Percutaneous coronary intervention,PCI)后即刻、术后1天、术后3天、术后7天、术后12个月后检测体内CF6的浓度,并于术后12个月行冠状动脉造影复查,用光学相干断层成像(Optical coherence tomography,OCT)检测内膜增生程度。结果:造影前和造影术后即刻患者血浆CF6水平没有明显差别(造影前CF6:215.65+14.39pg/m L,造影术后即刻CF6:216.75+14.40 pg/m L,P>0.05)。PCI术后即刻血浆CF6浓度较造影前增高(231.75+13.2 pg/m L,P<0.05),术后1天可达到高峰(262.4+14.06 pg/m L,P<0.05),3天后有所下降(239.86+13.15 pg/m L,P<0.05),但仍高于造影前水平,7天后可以恢复至造影前水平(222.4+15.06pg/m L,P>0.05)。术后1年随访时,血浆CF6水平是221.05+14.82 pg/m L,平均内膜增生厚度为0.158+0.014mm,平均内膜面积为0.134+0.057 mm2,患者内膜增生厚度与支架植入1天后血浆CF6峰值呈正相关(r=0.819,P<0.05)。内膜增生面积与PCI术后血浆CF6峰值水平正相关(r=0.729,P<0.05)。结论:冠心病患者术后CF6浓度峰值越高,其支架内膜增生越厚。Objective： To investigate the variation of CF6 concentration in patients with unstable coronary heart disease after stent implantation and explore the relationship between the degree of intimal hyperplasia and CF6. Methods： 20 patients with unstable coronary heart disease who met the inclusion criteria were included in this study. The levels of peripheral blood CF6 were detected before and instantly after angiography, 1 day, 3 days,7 days and 12 months after PCI. We detected CF6 level in the plasma of patients in the same way, and used OCT to detect coronary intimal hyperplasia1 year after PCI. Results： Plasma CF6 level showed no significant difference instantly after angiography compared with pre-angiography（pre-angiography： 215.65＋14.39 pg/m L, instantly after angiography：216.75＋14.40 pg/m L, P〉0.05）. Plasma CF6 in patients with coronary heart disease increased significantly instantly after PCI compared with the pre-angiography（instantly after PCI： 231.75＋13.2 pg/m L, P〈0.05）, reached to a peak point after 1day（262.4＋14.06 pg/m L）, declined significantly after 3 days（239.86＋13.15 pg/m L）, and returned to the pre-angiography level after 7 days 222.4＋15.06）. 1year follow-up after PCI, plasma CF6 level was 221.05＋14.82 pg/m L, the thickness of intimal hyperplasia was 0.158＋0.014 μm, the area of intimal was 0.134＋0.057 mm2. The thickness of intimal hyperplasia in patients was positively correlated with plasma CF6 peak（r=0.819,P〈0.05）. The area of intimal hyperplasia in patients was positively correlated with plasma CF6 peak（r=0.729, P〈0.05）. The higher the CF6 level, the more the intimal hyperplasia. Conclusions： The degree of intimal thickening was positively correlated with CF6 peak.

关 键 词：冠心病 不稳定型心绞痛 支架 内膜 线粒体偶联因子6 

分 类 号：R541.4[医药卫生—心血管疾病]