冠脉搭桥术后肺水肿患者氧化应激状态的变化观察  

Observation of the Changes of Oxidative Stress for Patients with Pulmonary Edema after Coronary Artery Bypass Surgery

作　　者：王小军[1] 王宗社[1] 舒瑞超 陈述[1] 马恩[1] 

机构地区：[1]陕西省宝鸡市中心医院心血管外科,陕西宝鸡721008

出　　处：《现代生物医学进展》2016年第23期4545-4547,4557,共4页Progress in Modern Biomedicine

基　　金：陕西省宝鸡市卫生局科研立项(2012-16号)

摘　　要：目的:研究冠脉搭桥术后肺水肿患者氧化应激状态变化观察,评价氧化应激状态与肺水肿的关联性,为临床减轻冠脉搭桥术后肺部并发症提供依据。方法:将本院2014年1月-2015年6月收治的冠脉搭桥术后肺水肿患者40例作为试验组,另选同期冠脉搭桥术后未发生肺水肿患者40例作为对照组。检测并比较两组患者术后3天、7天及14天的丙二醛(MDA)、总抗氧化能力(TAC)、过氧化氢酶(CAT)、C反应蛋白(CRP)、过氧化脂(LPO)及超氧化物歧化酶(SOD)的水平变化。结果:与对照组患者相比,试验组患者术后3 d、7 d、14 d三个时间点MDA,LPO及CRP表达水平均显著提高,而TAC,SOD及CAT表达水平均显著降低,差异均具有统计学意义(P<0.05)。与术后3 d相比,两组患者术后7 d、14 d两个时间点的MDA,LPO和CRP表达水平均显著降低,而TAC,SOD及CAT表达水平均显著提高,差异具有统计学意义(P<0.05)。结论:冠脉搭桥术后肺水肿的发生与患者氧化应激状态密切相关,机体自由基增多、抗氧化能力下降是肺水肿发生的重要机制。Objective： To study the changes of oxidative stress for patients with pulmonary edema after coronary artery bypass surgery, and evaluate the correlation of oxidative stress and pulmonary edema, so as to provide a reference for clinical research. Methods：40 cases with pulmonary edema who had taken the coronary artery bypass surgery in our hospital from January 2014 to June 2015 were selected as the research group, and another 40 cases without pulmonary edema were chosen to be the control group. Then the level changes of the malondiadehyde（MDA）, total antioxidant capacity（TAC）, catalase（CAT）, C-reactive protein（CRP）, lipid peroxide（LPO） and superoxide dismutase（SOD） after the operation for 3 days, 7 days and 14 days in the two groups were detected and compared.Results： Compared with the control group, the levels of MDA, LPO and CRP in the research group were higher, and the levels of TAC,SOD and CAT were lower after the operation for 3 days, 7 days and 14 days, and the differences were statistically significant（P〈0.05）.Compared with the third day after operation, the levels of MDA, LPO and CRP were higher and the levels of TAC, SOD and CAT were lower in the two groups after the operation for 7 days and 14 days, and the differences were statistically significant（P〈0.05）. Conclusion：The occurrence of pulmonary edema after coronary artery bypass surgery is closely related to patients with oxidative stress, the increase of free radicals and the decline of antioxidant capacity is the important mechanism of pulmonary edema.

关 键 词：冠脉搭桥术 肺水肿 氧化应激 

分 类 号：R541.4[医药卫生—心血管疾病] R654.2[医药卫生—内科学]