丹参酮ⅡA磺酸钠注射液对胃肠外科手术切口愈合的影响研究  

Effect of tanshinone ⅡA sodium injection on gastrointestinal surgical incision healing

作　　者：董军[1] 刘斌[1] 谭弟新 庄宁[1] 陈童[1] 王锋[1] 

机构地区：[1]济南市长清区人民医院普通外科,250300

出　　处：《中华普通外科学文献（电子版）》2016年第4期283-286,共4页Chinese Archives of General Surgery(Electronic Edition)

基　　金：济南市科学技术发展计划项目(201503018)

摘　　要：目的分析并探讨丹参酮ⅡA磺酸钠注射液促进胃肠外科手术切口愈合的临床效果,从而为临床治疗方案的选择提供依据。方法选择2014年1月至2015年6月收治的胃肠手术患者120例为研究对象,采用随机数字表的方法分为观察组与对照组,各60例。对照组患者给予常规应用抗生素及其他对症药物,观察组则在对照组的基础上加用丹参酮ⅡA磺酸钠注射液,比较两组患者切口愈合时间、不良情况发生率,术前及术后1、3、5 d的C反应蛋白(CRP)及全血黏度水平。结果观察组平均切口愈合时间为(7.06±0.71)d,对照组为(9.27±0.82)d,观察组切口愈合时间明显短于对照组(t=15.782,P<0.01)。对照组的切口感染率为10.00%(6/60),切口液化率为13.33%(8/60);观察组未发生切口感染病例,切口液化率为1.67%(1/60),经比较均高于对照组(c2=6.316、5.886,P=0.012、0.015)。两组患者术前CRP、全血黏度指标差异无统计学意义,术后观察组恢复更加明显(P<0.05)。结论丹参酮ⅡA磺酸钠注射液对于胃肠外科手术切口的愈合具有一定的促进作用,可有效地控制切口脂肪液化,加快患者切口一期愈合时间。Objective To analyze and discuss tanshinone ⅡA sodium injection in the clinical results of gastrointestinal surgery wound healing, so as to provide the evidence for clinical treatment. Methods One hundred and twenty cases of gastrointestinal surgery were selected from January 2014 to June 2015. They were randomly divided into observation group and control group using random number table method, with 60 cases in each group. The control group received routine treatment with antibiotics and other symptomatic drugs, and the observation group received additional tanshinone ⅡA sodium injection. The wound healing time, incidence of adverse events, pre-and post-operative 1, 3, 5 d level of C-reactive protein （CRP） and whole blood viscosity level between the two groups were compared. Results The average healing time of the observation group was （7.06±0.71） d, and （9.27±0.82） d in the control group;the healing time of the observation group was significantly shorter than that of the control group （t=15.782, P〈0.01）. In the control group, the infection rate of incision and incisional liquefaction rate were 10.00% （6/60） and 13.33%（8/60） respectively, significantly higher than those of the control group （0%and 1.67%, χ^2=6.316, 5.886, P=0.012, 0.015）. There was no significant difference in CRP and whole blood viscosity indexes between the two groups before and after operation, and the recovery time of observation group was more quickly （P〈0.05）. Conclusion TanshinoneⅡA sodium injection for parenteral surgical incision healing has certain benefit in controlling the incision fat liquefaction, and can speed up incisional healing time.

关 键 词：消化系统外科手术 伤口愈合 C反应蛋白质 丹参酮ⅡA磺酸钠 

分 类 号：R656[医药卫生—外科学]