372株溶血葡萄球菌的临床分布及耐药性  

Clinical distribution and drug resistance of Staphylococcus haemolyticus

作　　者：赖剑秀 孙龙[2] 宋相泉 

机构地区：[1]杭州市西湖区中西医结合医院检验科,浙江杭州310030 [2]武警浙江总队杭州医院检验科,浙江杭州310051

出　　处：《中国微生态学杂志》2016年第8期956-958,共3页Chinese Journal of Microecology

摘　　要：目的了解医院4年来溶血葡萄球菌的临床分布特征及耐药性变化,为临床合理用药提供参考依据。方法回顾性分析2010年1月至2013年12月住院患者标本分离的372株溶血葡萄球菌,采用美国BD Phoenix 100全自动细菌鉴定药敏分析仪及其配套GP检测卡进行药敏分析。结果分离的372株溶血葡萄球菌主要分布于ICU、呼吸内科和外科,主要来源于痰液、尿液和伤口分泌物;未检测到万古霉素耐药菌株,对阿莫西林/克拉维酸、氨苄西林、苯唑西林、红霉素、青霉素、头孢西丁均保持90%以上的高耐药性,对其它抗生素均存在不同程度耐药性。结论溶血葡萄球菌耐药现象日益严重,且多重耐药现象呈上升趋势,临床在治疗此类细菌感染时,应根据药敏试验结果制定用药方案,减少经验用药。Objective To investigate the change of clinical distribution and drug resistance of Staphylococcus haemolyticus during the last four years,and provide evidence for rational clinical use of drugs.Methods Three hundred and seventy-two strains of Staphylococcus haemolyticus isolated from inpatients from January 2010 to December 2013 were retrospectively analyzed,their drug susceptibility was detected using American automated bacteria identification and drug susceptibility analyzer BD Phoenix 100.Results The three hundred and seventy-two strains of Staphylococcus haemolyticus mainly distributed in ICU,respiratory medicine ward and respiratory surgery ward,most of which were isolated from sputum,urine and wound secretion.All the strains were sensitive to vancomycin,and the resistance rates to amoxycillin/clavulanic,Ampicillin,Oxacillin,Erythromycin,Penicllin G and Cefoxitin were over 90%.The strains exhibited different degrees of resistance to other antibiotics.Conclusion The resistance of Staphylococcus haemolyticus is increasingly getting higher,and multi-resistance is also increasing.Clinicians should use antibiotics according to results of susceptibility test instead of experiences treating infection of Staphylococcus haemolyticus.

关 键 词：溶血葡萄球菌 耐药性 抗生素 

分 类 号：R378[医药卫生—病原生物学]