栗锦迁教授治疗慢性舒张性心力衰竭的用药规律  

Analysis on Professor LI Jin-qian's Medication Regularity for Chronic Diastolic Heart Failure

作　　者：曹云[1] 李树茂[2] 裘东[2] 栗锦迁 

机构地区：[1]天津市和平区中医医院,天津300050 [2]天津市中医药研究院附属医院,天津300120

出　　处：《中国实验方剂学杂志》2016年第16期215-219,共5页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:分析和挖掘栗锦迁教授治疗慢性舒张性心力衰竭的用药组方规律。方法:收集栗锦迁教授治疗慢性稳定性舒张性心力衰竭的临床有效医案55例,通过"中医传承辅助平台(V2.5)"软件,采用频次分析、关联规则、复杂系统熵聚类及无监督的熵层次聚类等数据挖掘方法进行数据分析。结果:对筛选出的有效处方进行分析,得出64首方剂共包含70味药物,各种药物的使用频次总和为2 094次。其中党参、黄芪、川芎、枳壳、茯苓、桔梗、山茱萸、赤芍、麦冬及五味子出现的频次最高,且分别在用量30,50,20,15,30,15,30,20,15,20 g时使用频率最高。入组方剂中,频次在50次以上的3味及4味药物的组合分别为47及22组,频次在40次以上的5,6味及7味药物组合分别有155,67,10组,频次在35次以上的8味药物组合的有18组,频次在30次以上的9味药物组合有6组。通过药物之间的关联规则,演化得出核心组合7个,新处方2个。结论:栗锦迁教授辨治慢性舒张性心力衰竭总以益气温阳为纲,擅用补虚药补养心脏,配合活血、清热之品,共奏益气、养阴、行气、活血、祛痰之效。Objective： To analyze the composing principles of the prescriptions of professor Li Jin-qian for chronic diastolic heart failure based on Traditional Chinese Medicine （TCM） Inheritance Support System （V2.5）. Method： Efforts were made to collect 55 patients＇ prescriptions of chronic diastolic heart failure cases, enter the data into the TCM inheritance support system, and analyze the data by using frequency analysis, association rules, complex system entropy clustering and unsupervised hierarchical clustering. Result： Totally 64 prescriptions were screened out for the analysis, including 70 herbs. And the total frequency was 2 094.The most frequently used ones were Codonopsis Radix, Astragali Radix, Chuanxiong Rhizoma, Aurantil Fructus, Poria, Platycodonis Radix, Corni Fructus, Paeoniae Radix Rubra, Ophiopogonis Radix, Schisandrae Chinensis Fructus. They were often used at the dosage of 30, 50, 20, 15, 30, 15, 30, 20, 15,20 g. Among the prescriptions, there were 47 and 22 combinations of three and four herbs with the frequency of more than 50 times, 155, 67 and 10 combinations of five, six and seven herbs with the frequency of more than 35 times, and six combinations of nine herbs with the frequency of more than 30 times. Through the association rules among herbs, seven core combinations and two new prescriptions were evolved. Conclusion： Professor Li is good at using the principle of supplement Qi and warming Yang in treating chronic diastolic heart failure. Besides, he also applied deficiency-tonifying medicine to nourish the heart, and used blood-activating and heat-clearing medicines to replenish Qi, nourish Yin and Qi and motivate blood.

关 键 词：慢性舒张性心力衰竭 用药规律 中医传承辅助系统 

分 类 号：R287[医药卫生—中药学]