乙型肝炎病毒感染患者发病中CD_8^+T细胞的临床作用机制研究  

Clinical mechanism of CD_8^+ T cells in patients with hepatitis B virus infection

作　　者：润袁敏[1] 饶绘[1] 裴姣[1] 江华[1] 曹红[1] 朱宇芳[1] 

机构地区：[1]襄阳市中心医院医学检验部,湖北襄阳441021

出　　处：《中华医院感染学杂志》2016年第16期3625-3627,共3页Chinese Journal of Nosocomiology

基　　金：湖北省自然科学基金资助项目(2013CFB254)

摘　　要：目的研究CD8+T细胞在乙型肝炎病毒(HBV)感染患者发病中的临床作用机制,为临床控制HBV感染提供参考依据。方法选取2012年5月-2015年5月于医院接受治疗126例乙型肝炎患者为试验组,同期选择32名健康体检者为对照组,比较两组受试者生化指标等,数据采用SPSS 18.0软件进行统计分析。结果试验组患者血清丙氨酸氨基转移酶、天冬氨酸氨基转化酶、γ-谷氨酸转移肽酶、总胆红素、直接胆红素以及球蛋白水平明显高于对照组,差异有统计学意义(P<0.05)。结论 CD8+T细胞是控制HBV感染的关键,采取有效措施监测T细胞各种亚群及病毒载量,并开展有效的抗病毒治疗,将有利于提高患者HBV感染的治疗效果。OBJECTIVE To study the CD8＋T cells in clinical mechanisms of the pathogenesis of hepatitis B virus（HBV）infection,so as to provide reference for clinical control of HBV infection.METHODS A total of 126 cases of hepatitis B patients with HBV treated in hospital from May 2012 to May 2015 were selected as the experimental group,another 32 cases of the same period of alternative healthy people as control group.These two groups were under comparison of biochemical indexes.SPSS 18.0was used for data analysis.RESULTS In the experimental group,the serum levels of alanine aminotransferase,aspartate amino invertase,γ-glutamate transfer peptide enzyme,total bilirubin,direct bilirubin and globulin were significantly higher than those in the control group（P〈0.05）.CONCLUSIONCD8＋T cells is the key to control HBV.Effective measures should be taken to monitor a variety of T cell subsets and viral load.The treatment for anti-viral is necessary which could help to improve the treatment of patients with HBV infection.

关 键 词：CD8+T细胞 HBV感染 临床作用机制 

分 类 号：R512.62[医药卫生—内科学]