急性心肌梗死患者巨细胞病毒感染与炎症因子的关系研究  

Relationship between cytomegalovirus infection in patients with acute myocardial infarction and its inflammatory factors

作　　者：余波[1] 艾芬[1] 李维[1] 付晓幸 白祥琰 

机构地区：[1]华中科技大学同济医学院附属武汉中心医院急诊科,湖北武汉430014

出　　处：《中华医院感染学杂志》2016年第16期3663-3665,共3页Chinese Journal of Nosocomiology

基　　金：湖北省卫生计生科研基金资助项目(WJ2015HA005)

摘　　要：目的探讨巨细胞病毒(CMV)感染与急性心肌梗死和相关炎症因子之间的相关性,为临床诊断和治疗提供参考依据。方法选择2014年6月-2015年12月医院收治的72例急性心肌梗死急性期患者为急性心梗组、72例心肌梗死恢复期患者为恢复期心梗组、72例陈旧性心肌梗死患者为陈旧性心梗组以及70例非冠心病患者为非冠心病组;采用酶联免疫吸附试验(ELISA)测定4组患者的相关炎症因子水平,数据采用SPSS 21.0软件进行统计分析。结果急性心梗组、恢复期心梗组、陈旧性心梗组患者的白细胞介素(IL)-6、可溶性细胞间黏附分子(sICAM-1)、可溶性CD14(sCD14)高于非冠心病组,并且急性心梗组IL-6、sICAM-1、sCD14高于恢复期心梗组、陈旧性心梗组,差异有统计学意义(P<0.05);校正影响因素后,CMV IgG与IL-6、sICAM-1、CRP、sCD14有较好的相关性。结论急性CMV感染与急性心肌梗死的发生及发展密切相关,可能通过引起或加重冠状动脉的炎症反应,而参与急性心肌梗死的病理生理过程。OBJECTIVE To explore the relationship between cytomegalovirus（CMV）infection and acute myocardial infarction and its inflammatory factors,so as to provide guidance for clinical diagnosis and treatment.METHODS A total of 72 patients with acute myocardial infarction（AMI group）,72AM2 patients in recovery phase（recovery AMI group）,72 patients with old myocardial infarction（OMI group）and 70 patients with non coronary heart disease（non CHD group）in hospital from Jun.2014 to Dec.2015 were collected.The inflammatory factors were tested by enzyme-linked immunosorbent assay（ELISA）for four groups.SPSS 21.0was used for data analysis.RESULTS The interleukin-6（IL-6）,soluble intercellular adhesion molecule（sICAM-1）and sCD14 in AMI group,recovery AMI group and OMI group were higher than those in non CHD group.The IL-6,sICAM-1and sCD14 in AMI group were higher than those in recovery AMI group and OMI group（P〈0.05）.After adjust the influence factors,there were positive relationship between CMV IgG and IL-6,sICAM-1,CRP,and sCD14.CONCLUSION Acute CMV infection has closely correlation with occurrence and development of acute myocardial infarction,which may be involved in the pathophysiological process of acute myocardial infarction by causing or aggravating in inflammatory reaction of coronary arteries.

关 键 词：巨细胞病毒 急性心肌梗死 炎症因子 相关性 

分 类 号：R446[医药卫生—诊断学]