先天性心脏病介入治疗后医院感染患者血浆游离氨基酸与肺功能的变化研究  

Changes of plasma free amino acids and pulmonary function of patients with nosocomial infections after interventional treatment of congenital heart disease

作　　者：汪砚雨[1] 王绍欣[1] 董平栓[1] 刘相勇[1] 赵飞龙[1] 

机构地区：[1]河南科技大学第一附属医院心内科,河南洛阳471003

出　　处：《中华医院感染学杂志》2016年第16期3671-3673,共3页Chinese Journal of Nosocomiology

基　　金：河南省科技厅基金资助项目(2013098934H)

摘　　要：目的研究先天性心脏病介入治疗后医院感染患者血浆游离氨基酸与肺功能的变化情况,为术后医院感染的治疗与预防控制提供参考依据。方法选取2011年1月-2015年10月于医院进行治疗的46例先天性心脏病介入治疗术后医院感染患者为观察组,同期选取46例先天性心脏病介入治疗术后未发生医院感染的患者为对照组,将两组患者的血浆游离氨基酸与肺功能指标进行比较,数据采用SPSS 15.0软件进行统计分析。结果观察组患者血浆苏氨酸、异亮氨酸及亮氨酸分别为(401.56±62.34)μmol/L、(52.62±4.98)μmol/L及(84.64±7.82)μmol/L,均低于对照组,血浆丙氨酸水平为(315.94±30.87)μmol/L,高于对照组的(282.12±27.63)μmol/L,差异有统计学意义(P<0.05)。结论先天性心脏病介入治疗术后医院感染患者血浆游离氨基酸与肺功能处于相对较差的状态,而呼吸道感染对患者肺功能造成更大的不良影响,应引起重视。OBJECTIVE To study and observe the changes of plasma free amino acids and pulmonary function of patients with nosocomial infections after interventional treatment of congenital heart disease,in order to provide evidence for the treatment,prevention and control of postoperative nosocomial infections.METHODS A total of 46 patients with nosocomial infections after interventional treatment of congenital heart disease in hospital from Jan.2011 to Oct.2015 were selected as observation group,another 46 patients without nosocomial infections after interventional treatment of congenital heart disease at the same time were selected as control group.Then the plasma free amino acids and pulmonary function indexes of two groups were compared.The data were analyzed by SPSS15.0.RESULTS The plasma threonine,isoleucine and leucine levels of observation group were respectively（401.56±62.34）μmol/L,（52.62±4.98）μmol/L and（84.64±7.82）μmol/L,which were all lower than those of control group.The plasma alanine level of observation group was（315.94±30.87）μmol/L,which was higher than that of control group（P〈0.05）.CONCLUSIONThe plasma free amino acids and pulmonary function of patients with nosocomial infections after interventional treatment of congenital heart disease are in a relatively worse state,and the bad influence of respiratory infection for the pulmonary function of patients are greater,so it should be paid more attention.

关 键 词：先天性心脏病 介入治疗 医院感染 血浆游离氨基酸 肺功能 

分 类 号：R541.1[医药卫生—心血管疾病]