乳腺癌患者根治术后切口感染甲襞微循环与细胞因子变化观察  

Observation on the changes of nailfold microcirculation and cytokines of patients with infection of incisional wound after radical mastectomy for breast cancer

作　　者：王灿[1] 江华[2] 郭琪[1] 郭伟胜[3] 洪文静[1] 

机构地区：[1]河南省中医院乳腺外科,河南郑州450002 [2]河南中医药大学基础医学院,病原免疫生物学科河南郑州450046 [3]河南省中医院肿瘤外科,河南郑州450002

出　　处：《中华医院感染学杂志》2016年第16期3768-3770,共3页Chinese Journal of Nosocomiology

基　　金：河南省卫生厅重点基金资助项目(2013390165X)

摘　　要：目的观察乳腺癌根治术切口感染患者甲襞微循环与细胞因子的变化情况,为乳腺手术患者术后感染的预防控制提供参考依据。方法选取2011年10月-2015年10月医院诊治的28例乳腺癌根治术切口感染患者为观察组,同期选取28例未发生感染的乳腺癌根治术患者为对照组,将两组患者甲襞微循环指标、白细胞介素、干扰素及肿瘤坏死因子水平进行比较,数据采用SAS 6.0软件进行统计分析。结果观察组的甲襞微循环指标中的白微栓率、红细胞聚集率、输入支管径及输出支管径分别为(2.05±0.32)%、(1.54±0.19)%、(5.04±0.60)μm及(6.17±0.64)μm,均低于对照组,观察组的血清白细胞介素、干扰素及肿瘤坏死因子水平均低于对照组,差异均有统计学意义(P<0.05)。结论乳腺癌根治术切口感染患者甲襞微循环与细胞因子的变化较大,且浅表感染和深部组织感染差异也较大,应针对感染情况给予针对性治疗。OBJECTIVE To observe the change status of nailfold microcirculation and cytokines of patients with infection of incisional wound after radical mastectomy for breast cancer,in order to provide references for the control and prevention of postoperative infection of breast cancer operation.METHODS A total of 28 patients with infection of incisional wound after radical mastectomy for breast cancer in hospital from Oct.2011 to Oct.2015 were selected as observation group,another 28 patients of the same age without infection after radical mastectomy for breast cancer were selected as control group,then the nailfold microcirculation indexes,interleukins,interferons and tumor necrosis factors of the two groups were compared.The data were analyzed by SAS 6.6.RESULTS The white microthrombus rate,erythrocyte aggregation rate,input tube diameter and output tube diameter of nailfold microcirculation indexes of observation group were（2.05±0.32）%,（1.54±0.19）%,（5.04±0.60）μm and（6.17±0.64）μm,respectively,and they were all lower than those of control group;the serum interleukins,interferons and tumor necrosis factors of observation group were all lower than those of control group,all had significent differences（P〈0.05）.CONCLUSION The changes of nailfold microcirculation and cytokines of patients with infection of incisional wound after radical mastectomy for breast cancer are significent,and the results′differences of patients with superficial infection and deep tissue infection are significent too,so the infection situation should be paid targeted treatment.

关 键 词：乳腺癌根治术 切口感染 甲襞微循环 细胞因子 

分 类 号：R655.8[医药卫生—外科学]