肝功能异常对乙型肝炎病毒感染孕妇母婴结局的影响  

Abnormal liver function on maternal and neonatal outcomes of HBV infection in pregnant women

作　　者：赵书杰[1] 李宛玲[1] 吴祖辉[1] 张桂萍[1] 王莉[1] 

机构地区：[1]南阳市第一人民医院妇产科,河南南阳473000

出　　处：《中华医院感染学杂志》2016年第16期3794-3796,共3页Chinese Journal of Nosocomiology

基　　金：国家自然科学基金资助项目(81000505)

摘　　要：目的分析探讨肝功能异常对乙型肝炎病毒(HBV)感染孕妇母婴结局的影响,进一步为临床降低感染率提供相关的理论指导依据。方法选取2013年3月-2015年2月于医院产科收治的55例妊娠期感染HBV(血清检测HBsAg呈阳性)孕妇为研究对象,根据孕妇谷丙转氨酶(ALT)和谷草转氨酶(AST)水平,将其分为肝功能正常组26例和肝功能异常组29例,同期选取于医院产检肝功能正常且血清检测HBsAg阴性的孕妇50例为对照组,比较3组孕妇指标及婴儿生存状况。结果肝功能异常组孕妇在产后出血、妊娠期高血压、胎膜早破、早产及胎儿窘迫等并发症的发生率明显高于其他两组;异常组出现低体重儿、死胎及新生儿窒息的概率最高,与其他两组比较,差异均有统计学意义(P<0.05)。结论妊娠期合并HBV感染易增加孕妇妊娠及分娩其并发症的发生率,同时易导致新生儿肺炎、胎儿窘迫、低体重儿等的发生率,特别是肝功能异常孕妇对母婴的危害更为严重,需引起注意。OBJECTIVE To investigate the effect of abnormal liver function to chronic hepatitis B（HBV）infection on pregnant mother and child outcomes,so as to provide theoretical guidance and basis to further reduce the rate of infection for clinic.METHODS A total of 55 cases of infection during pregnancy HBV（HBsAg positive sera）patients treated in hospital maternity from Mar.2013 to Feb.2015 were selected for this study,according to the patient alanine aminotransferase（ALT）and aspartate aminotransferase（AST）levels who were divided into normal liver function group（26cases）and abnormal liver function group（29cases）.Another 50 cases of pregnant women with normal liver function and HBsAg negative sera at the same period who came to our hospital were select as control group.Clinical indexes of pregnant women and their infants survival status situation were compared amory these three groups.RESULTS The tests results showed the incidence of postpartum hemorrhage,gestational hypertension,premature rupture of membranes,premature delivery and fetal distress and other complications in abnormal liver function group was significantly higher than the other two groups.There was the highest incidence of low birth weight children,stillbirth and neonatal asphyxia in abnormal group the difference was significance（P〈0.05）.CONCLUSION Gestation period with HBV infection is likely to increase the incidence of complications during gestation period and delivery period,which could easily lead to neonatal pneumonia,fetal distress,low birth weight children and so on incidence.Especially in pregnant women with abnormal liver function which could lead to more serious harm to mother and child,and the attention should be needed.

关 键 词：乙型肝炎病毒 感染 肝功能异常 母婴结局 影响 

分 类 号：R512.62[医药卫生—内科学]