阿奇霉素对肺炎支原体肺炎感染患儿Th1/Th2指标的影响研究  

Effect of azithromycin on Th1/Th2 Indexes in children with Mycoplasma pneumoniainfection

作　　者：李晓品[1] 李艳红[2] 许凤勤 陈梦丽[1] 史云菊[3] 

机构地区：[1]河南省商水县人民医院儿内科,河南商水县466100 [2]周口市中心医院儿内科,河南周口466000 [3]郑州铁路职业技术学院护理学院,河南郑州451460

出　　处：《中华医院感染学杂志》2016年第16期3797-3799,共3页Chinese Journal of Nosocomiology

基　　金：河南省科技厅基金资助项目(20132098453K)

摘　　要：目的研究阿奇霉素在肺炎支原体肺炎患儿临床治疗效果及Th1/Th2指标的影响,为提高临床治愈率提供参考依据。方法选取2014年12月-2015年12月医院诊治的96例肺炎支原体肺炎患儿资料进行分析,将患儿根据随机数字方法分为试验组和对照组,各48例;对照组采用红霉素治疗,试验组采用阿奇霉素治疗,比较两组患儿对Th1/Th2指标的影响。结果试验组治疗后Th1/Th2、IFN-γ以及IFN-γ/IL-4,显著低于对照组(P<0.05);试验组治疗后药物不良反应发生率为8.33%,显著低于对照组的29.17%(P<0.05)。结论与红霉素治疗相比,在肺炎支原体肺炎患儿采用阿奇霉素治疗效果理想,能改善机体免疫,降低感染率,值得推广应用。OBJECTIVE To study the clinical effect of azithromycin on Mycoplasma pneumonia in children and its effect on Th1/Th2 indicators so as to provide the basis for improving clinical cure rate.METHODS Totally 96 cases of children with M.pneumoniae pneumonia admitted from Dec.2014 to Dec.2015 were selected and their clinic data were analyzed.The children were divided into experiment group and control group according to the method of random numbers,each with 48 cases.The control group was treated with erythromycin and the experiment group was treated with azithromycin.The changes of Th1/Th2 in the two groups were compared.RESULTS Th1/Th2,IFN-γand IFN-γ/IL-4levels of experimental group were significantly lower than the control group after treatments（P〈0.05）.The adverse reaction rate of the experiment group was 8.33%,significeatly lower than the control group with 29.17%（P〈0.05）.CONCLUSIONCompared with erythromycin,azithromycin is proved to have better efficacy in treating M.pneumoniain children and it can improve immunity,reduce infection,hence should be widely applied.

关 键 词：阿奇霉素 红霉素 肺炎支原体肺炎 Th1/Th2指标 

分 类 号：R725.6[医药卫生—儿科]