阿托伐他汀联合普罗布考对高血压患者血管弹性的影响  

Effects of Atorvastatin Combined with Probucol on the Vascular Elasticity in Patients with Hypertension

作　　者：董晓柳[1] 徐士军[1] 张秀清[1] 朱丽霞[1] 

机构地区：[1]唐山市人民医院神经内科,河北唐山063000

出　　处：《中国药房》2016年第23期3243-3245,共3页China Pharmacy

摘　　要：目的:探讨阿托伐他汀联合普罗布考对高血压患者血管弹性的影响。方法:选取高血压患者246例,采用随机数字表法分为对照组和观察组,各123例。两组患者均进行常规降压治疗。在此基础上,对照组患者口服阿托伐他汀片10 mg,qd;观察组患者在对照组基础上加服普罗布考片0.25 g,qd。两组患者均治疗1年。观察两组患者临床疗效及治疗前后血脂水平(总胆固醇、三酰甘油、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇)、胱抑素C(Cys-C)、C反应蛋白(CRP)、颈总动脉和下肢动脉弹性参数(僵硬度、压力应变弹性系数、顺应性、增大指数、脉搏波传导速度),并比较不良反应发生情况。结果:两组患者治疗前血脂水平、Cys-C、CRP、颈总动脉和下肢动脉弹性参数比较,差异均无统计学意义(P>0.05);治疗后,两组患者上述指标较治疗前均显著改善,且观察组患者改善程度明显优于对照组,差异均有统计学意义(P<0.05)。两组患者均未见明显不良反应发生。结论:阿托伐他汀联合普罗布考能明显改善高血压患者血脂水平及颈总动脉和下肢动脉弹性,且安全性较好。OBJECTIVE：To explore the effects and safety of atorvastatin combined with probucol on the vascular elasticity in patienits with hypertension. METHODS：246 hypertensive patients were randomly divided into control group and observation group,123 cases in each group. All patients received conventional antigypertensive treatment,based on it,control group was given10 mg Atorvastatin tablet,qd;observation group was additionally given 0.25 g Probucol tablet,qd,on the basis of control group.They were treated for 1 year. Clinical efficacy,lipid levels（total cholesterol,triglyceride,low density lipoprotein cholesterol,high density lipoprotein cholesterol）,cystatin C（Cys-C）,C-reactive protein（CRP）,elastic parameters of common carotid artery and lower limb artery（stiffness,pressure-strain elastic modulus,compliance,augmentation index,pulse wave velocity）before and after treatment in 2 groups were observed,and the incidence of adverse reactions was compared. RESULTS：Before treatment,there were no significant differences in lipid levels,Cys-C,CRP and elastic parameters of common carotid artery and lower between 2groups（P〉0.05）;after treatment,the above-mentioned indexes were significantly improved,and the improvement degree in observation group was superior to control group,the differences were statistically significant（P〈0.05）. And there were no severe adverse reactions during treatment in both 2 groups. CONCLUSIONS：Atorvastatin combined with probucol can improve lipid level and elasticity of common carotid artery and lower limb artery,with good safety.

关 键 词：阿托伐他汀 普罗布考 高血压 颈总动脉 下肢动脉 

分 类 号：R493[医药卫生—康复医学]