银杏叶提取物联合奥美沙坦酯治疗原发性高血压的疗效及其对血清蛋白表达的影响  

Clinical Efficacy of Ginkgo biloba Extract Combined with Olmesartan Medoxomil in the Treatment of Essential Hypertension and Its Effect on the Expression of Serum Protein

作　　者：徐静雯[1,2] 王楠[3] 

机构地区：[1]山东中医药大学临床医学院,济南250011 [2]山东省医学科学院附属医院心血管内科,济南250031 [3]山东省肿瘤医院外科九病区,济南250112

出　　处：《中国药房》2016年第23期3257-3260,共4页China Pharmacy

摘　　要：目的：观察银杏叶提取物联合奥美沙坦酯治疗原发性高血压的临床疗效与安全性,并探讨其对血清蛋白表达的影响。方法：选取98例原发性高血压患者,按照随机数字表法分为观察A组和观察B组,各49例;纳入40名健康志愿者为对照组。观察A组患者给予奥美沙坦酯片20~40 mg,po,qd;观察B组患者给予奥美沙坦酯片20~40 mg,po,qd＋银杏叶提取物片40~80 mg,po,bid,疗程均为4周。观察3组受试者血压[收缩压（SBP）和舒张压（DBP）]、中医证候评分、2-DE图谱的重复性和分辨率、蛋白质差异表达点、差异表达蛋白质的相关信息和观察组患者的不良反应发生情况。结果：治疗后,观察组患者SBP、DBP、中医证候评分均明显低于治疗前,且治疗后4周明显低于治疗后2周,观察B组明显低于观察A组,差异均有统计学意义（P〈0.05）。观察B组患者治疗后的蛋白质差异表达点的重复性和分辨率明显优于观察A组。观察组治疗前15个蛋白质点表达下调,治疗后均表现为不同程度上调,且观察B组较观察A组更接近对照组水平;6个蛋白质点表达上调,治疗后均表现为不同程度下调,且观察B组较观察A组更接近对照组水平;共鉴定出11个蛋白质点。观察A组和观察B组患者不良反应发生率比较,差异无统计学意义（P〉0.05）。结论：银杏叶提取物联合奥美沙坦酯治疗原发性高血压对患者的血清蛋白表达影响较大,具有较理想的降压、控压效果,且安全性较高。OBJECTIVE：To observe clinical efficacy and safety of Ginkgo biloba extract combined with olmesartan medoxomil in the treatment of essential hypertension,and to discuss its effect on the expression of serum protein. METHODS：98 patients with essential hypertension were selected and randomly divided into observation group A and observation group B,with 49 cases in each group;40 healthy volunteers were included in control group. Observation group A was given Olmesartan medoxomil tablet 20-40 mg,po,qd;observation group B was given Olmesartan medoxomil tablet 20-40 mg,po,qd＋ Extract of G. biloba leaves tablet 40-80 mg,po,bid. Treatment course lasted for 4 weeks. Blood pressure（SBP and DBP）,TCM symptom score,the repetitiveness and resolution ratio of 2-DE spectrum,protein differentiation expression point,related information of differentiation expression protein in 3 groups and ADR of observation group were observed. RESULTS：After treatment,SBP,DBP and TCM symptom score of observation group were significantly lower than before;those indexes after 4 weeks of treatment were significantly lower than those after 2 weeks after treatment;the observation group B was significantly lower than the observation group A,with statistical significance（P〈0.05）. The repetitiveness and resolution ratio of protein differentiation expression point in observation group B were significantly better than in observation group A after treatment. The expression of 15 protein points in observation group down-regulated before treatment,and up-regulated after treatment to different extents;the observation group B was closer to control group,compared to observation group A. The expression of 6 protein points up-regulated,and then down-regulated to different extent after treatment;the observation group B was closer to control group,compared to observation group A. A total of 11 protein points were identified. There was no statistical significance in the incidence of ADR between observation group A and observation group B（P〉0.05）

关 键 词：银杏叶提取物 奥美沙坦酯 原发性高血压 血清蛋白表达 

分 类 号：R544[医药卫生—心血管疾病]