基于环糊精包合的超分子水凝胶骨修复材料  

Supramolecular Cyclodextrin Hydrogel as Bone Repair Material

作　　者：王伟钢[1] 林再富[1] 徐莉莎[1] 丁春梅[1] 李建树[1] 

机构地区：[1]四川大学高分子科学与工程学院,高分子材料工程国家重点实验室,四川成都610065

出　　处：《高分子材料科学与工程》2016年第8期28-31,37,共5页Polymer Materials Science & Engineering

基　　金：国家自然科学基金资助项目(51322303,51573110)

摘　　要：分别合成聚β-环糊精作为主体分子及侧链含有金刚烷胺和阿仑膦酸的聚合物作为客体分子,对其化学结构与相对分子质量进行了核磁共振氢谱表征。通过环糊精和金刚烷胺的主客体的分子相互作用得到一种物理交联的超分子水凝胶。通过对聚β-环糊精溶液粒径大小的表征,发现其粒径均匀,平均粒径大小为8.773 nm。倒立法研究发现,主客体分子比例为8∶1时形成的凝胶粘附性能最强。通过流变测试,验证了水凝胶的凝胶化过程。该体系中的阿仑膦酸基团能为水凝胶和骨创伤界面提供强的粘合作用,因而本体系可用于制备可注射水凝胶应用于骨修复领域。β-Cyclodextrin polymer was synthesized as host molecule and a polymer containing amantadine and alendronate group was synthesized as guest molecule. The chemical structure was characterized by 1H-NMR. Then, a type of suprarnolecular hydrogel was formed through the host-guest molecular interaction and physical crosslinked by β- cyclodextrins and amantadine. The hydrodynamic diameter distribution was characterized by dynamic light scattering（DLS）, the results show that β-cyclodextrin polymer has an uniform distribution as the average particle size is 8. 773 nm. The hydrogel adhesive property performs strongest when the host-guest ratio is 8：1. The gelation process of hydrogels was verified by rheological test. Amantadine in the system can provide strong adhesion between the gel and bone trauma interface, thus this system could be used for injectable bone repair hydrogels.

关 键 词：环糊精 金刚烷 水凝胶 骨修复 超分子作用 

分 类 号：O636.1[理学—高分子化学]