复发性多软骨炎54例临床分析  

Clinical analysis of 54 patients with relapsing polychondritis

作　　者：高冠民[1] 江东彬 蒋莉[2] 李艳敏[1] 郑晓龙[1] 张蕾蕾[1] 刘升云[1] 郑朝晖[1] 阚全程[3] 

机构地区：[1]郑州大学第一附属医院风湿免疫科 河南省高等学校临床医学重点学科开放实验室,450052 [2]郑州大学第一附属医院放射治疗部,450052 [3]郑州大学第一附属医院药学部

出　　处：《中华风湿病学杂志》2016年第8期556-559,共4页Chinese Journal of Rheumatology

摘　　要：目的分析复发性多软骨炎（RPC）的临床特征及治疗转归的规律。方法回顾性分析2010年1月至2015年12月在郑州大学第一附属医院确诊的RPC54例的临床特点。结果54例患者共住院85例次，从首次症状到确诊中位时间为4个月。CT是发现气道受累的最主要检查方法，喉镜和气管镜能早期发现黏膜和软骨损害，病理上大多以淋巴细胞和中性粒细胞浸润为主。大部分患者对糖皮质激素联合免疫抑制剂治疗反应较好，气道病变和合并感染是影响患者预后的最主要因素。结论RPC可累及全身多个系统，糖皮质激素和免疫抑制剂是主要的治疗方法。Objective To analyze the clinical features and treatment outcome of relapsing polychondritis （RPC）. Methods A retrospective analytic study of 54 patients fulfilled with the Damiani and Levine＇s modification of McAdam＇s diagnostic criteria of RPC in the first Affiliated Hospital of Zbengzhou University from January 2010 to December 2015 were conducted. Results Fifty-four patients hospitalized for 85 person-times. The median time from the first time to see a doctor to the diagnosis confirmation was 4 months. CT was the main method to discover the airway involvement. The pathologic changes in most patients were lympbocytes and neutropbils infiltration. Most patients responsed to glucocorticoids combined with immunosuppressant therapy. Airway involvement and infection were the main factors influencing the prognosis. Conclusion RPC is a multiple system diseases. Disease inflammation index detection is of great significance to judge the disease activity. Most patients have good response to glucocorticoids with immunosuppressant therapy.

关 键 词：多软骨炎 复发性 临床诊断 治疗 

分 类 号：R593.2[医药卫生—内科学]