pH敏感型葡萄糖基水凝胶的制备及溶胀性能测试  

Preparation and Swelling Property of pH-Sensitive Glucose-based Hydrogels

作　　者：林艳[1,2,3,4] 房桂干[1,2,3,4] 

机构地区：[1]中国林业科学研究院林产化学工业研究所 [2]生物质化学利用国家工程实验室 [3]国家林业局林产化学工程重点开放性实验室 [4]江苏省生物质能源与材料重点实验室,江苏南京210042

出　　处：《林产化学与工业》2016年第4期73-78,共6页Chemistry and Industry of Forest Products

基　　金：江苏省生物质能源与材料重点实验室一般项目资助(JSBEM-S-201510)

摘　　要：以葡萄糖为模板化合物,利用甲基丙烯酸缩水甘油醚对其改性后与丙烯酸、丙烯酰胺进行共聚反应,再经冷冻干燥,制备了具有pH值敏感特性的葡聚糖基水凝胶,并表征了其结构,优化了制备条件。结果表明:最佳条件为葡萄糖/丙烯酸/丙烯酰胺质量比为1∶4∶4,交联剂用量0.5%,引发剂用量1%,反应温度为65℃,在此条件下,水凝胶的平衡溶胀度可达90.5 g/g。研究发现该葡聚糖基水凝胶在同一pH值介质中的溶胀度随时间延长而增大,最后趋于平衡;其在无酶人工肠液(p H值7.4)中的溶胀度明显高于无酶人工胃液(pH值1.2),且该凝胶在两种介质中基本无降解。Glucose, as the template compound, was modified by glycidyl methacrylate and copolymerized with acrylic acid and acrylamide. After freeze drying, the pH-sensitive glulose-based hydrogels were obtained. The experimental conditions were studied and the optimal conditions were the 1：4：4 mass ratio of glucose/acrylic acid/acrylic amide, the 0.5% dosage of cross- linking agent, initiator and reaction temperature at 65 ℃. And the swelling ratio of hydrogel obtained under these conditions was about 90.5 g/g. Additionally, it was found that the swelling ratio of the glulose-based hydrogel increased with time extension and finally approached equilibrium in certain pH medium. And the swelling ratio of the hydrogels in the intestinal fluid without enzymes （ pH = 7.4） was significantly higher than that in the gastric fluid without enzymes （ pH = 1.2）. Moreover, the hydrogels could keep basically no degradation in the two kinds of medium. This showed certain application prospect in tissue engineering materials.

关 键 词：水凝胶 PH响应 葡萄糖 溶胀性能 

分 类 号：TQ35[化学工程] O629.12[理学—有机化学]