基于纤维束的空间统计方式的复发缓解型多发性硬化患者磁共振扩散张量成像与正常人对照  

Evaluating DTI of RRMS patients and normal controls based on TBSS

作　　者：秦耿耿[1] 代月黎[1] 陈卫国[1] 欧阳晨雨[1] 何子龙[1] 曾辉[1] 马乐[1] 吴元魁[1] 

机构地区：[1]南方医科大学南方医院放射科,广东广州510515

出　　处：《中国医学物理学杂志》2016年第8期799-804,共6页Chinese Journal of Medical Physics

基　　金：广东省科技计划项目(2015B020233002;2015B020233008;2016ZC0058);广州市科技计划项目(201604020058)

摘　　要：目的:利用基于纤维束的空间统计(TBSS)方式结合磁共振扩散张量成像技术(DTI)综合评价DTI对复发缓解型多发性硬化(RRMS)患者全脑白质微结构改变与正常人的对比,并探讨其应用价值。方法:实验组和对照组均进行全脑轴位常规扫描及DTI扫描,数据进行TBSS后处理,生成三维平均各向异性系数纤维骨架并进行非参数统计比较。结果:RRMS患者全脑双侧额叶、颞叶、顶叶及枕叶脑白质区域纤维素呈广泛性各向异性系数值减低、平均扩散率值升高,差异有统计学意义(P<0.05)。结论:RRMS患者双侧额叶、颞叶、顶叶及枕叶脑白质区存在广泛的脑白质损伤,TBSS后处理方法能较为准确地定位和定量监测、评估及发现RRMS病灶。Objective To comprehensively evaluate the effect of diffusion tensor imaging（DTI） on the microstructure of whole brain white matter of patient with relapsing-remitting multiple sclerosis（RRMS） and that of normal controls by using tract-based spatial statistics（TBSS） combined with DTI, and to discuss on the application value of TBSS combined with DTI. Methods The experimental group and control group underwent routine scan of whole brain shaft and DTI scan. The TBSS post-processing method was used to process the obtained data, generating three-dimensional average fractional anisotropy（FA） fiber skeleton,and the nonparametric statistical comparison was performed. Results The fiber of whole brain bilateral frontal lobe, temporal lobe, parietal and occipital lobe brain white matter of RRMS patients showed extensive reduction of FA value, increased mean diffusivity value, with statistically significant（P〈0.05）. Conclusion RRMS patients show extensive cerebral white matter lesions in bilateral frontal lobe, temporal lobe, parietal and occipital lobe brain white matter regions. TBSS post-processing method can accurately locate and quantitatively monitor, evaluate and find RRMS lesions.

关 键 词：多发性硬化 扩散张量成像 复发缓解型 基于纤维束的空间统计 

分 类 号：R445.2[医药卫生—影像医学与核医学]