机械电反馈与心房颤动  

Mechano-electric Feedback and Atrial Fibrillation

作　　者：郭秋哲[1] 刘小菁[2] 石应康[1] 

机构地区：[1]四川大学华西医院心脏及大血管外科,成都610041 [2]四川大学华西医院再生医学研究中心心血管疾病研究室,成都610041

出　　处：《生物医学工程学杂志》2016年第4期801-805,共5页Journal of Biomedical Engineering

摘　　要：心房颤动是常见而顽固的房性心律失常,心房力学或机械环境改变与房颤发生发展关系密切。机械因素可通过诱导心房电-解剖重构,导致心肌自律性及触发活动增加,传导速度减慢,有效不应期缩短,并最终使房颤易患性增加。其中细胞内钙离子稳态、细胞骨架结构及功能、局部肾素-血管紧张素-醛固酮系统、整合素及丝裂原活化蛋白激酶信号通路等参与上述过程。本文系统地介绍了与心房颤动相关的机械电反馈过程,对该领域内相关研究进行归纳整理,旨在为进一步研究并阐明房颤的力学机制提供理论依据。Atrial fibrillation is a common and refractory atrial arrhythmia.Changes of atrial mechanical circumstances are closely related to the occurrence and maintenance of atrial fibrillation.Mechanical factors can increase the automaticity,slow conduction velocity and shorten the effective refractory period of the atrium by causing electrical and structural remodeling,and eventually increase the inducibility of atrial fibrillation.The intracellular calcium level,function and structure of cytoskeleton,local renin-angiotensin system,integrin and mitogen-activated protein kinases（MAPKs）pathway might take part in the process.Here we analyze and review the underlining mechano-electric feedback process of atrial fibrillation and its related research in order to provide a theoretical basis for further research and elucidating of the mechanical mechanism of atrial fibrillation.

关 键 词：机械电反馈 心房颤动 机制 

分 类 号：R541.75[医药卫生—心血管疾病] R654.2[医药卫生—内科学]