Production of medical radioisotope ^(64)Cu by photoneutron reaction using ELI-NP γ-ray beam  

作　　者：Wen Luo 

机构地区：[1]School of Nuclear Science and Technology, University of South China [2]Extreme Light Infrastructure - Nuclear Physics (ELI-NP)/‘‘Horia Hulubei’’, National Institute for R&D in Physics and Nuclear Engineering (IFIN-HH)

出　　处：《Nuclear Science and Techniques》2016年第4期147-151,共5页核技术（英文）

基　　金：supported by Extreme Light Infrastructure-Nuclear Physics(ELI-NP)-Phase I;a project co-financed by the European Union through the European Regional Development Fund;the National Natural Science Foundation of China(No.11405083);the Young Talent Project of the University of South China

摘　　要：Copper-64 is a radioisotope of medical interest that could be used for positron emission tomography imaging and targeted radiotherapy of cancer. In this work,we investigated the possibility of producing the^(64)Cu isotope through a^(65)Cu(γ,n) reaction using high-intensity γ-beams produced at the Extreme Light InfrastructureNuclear Physics facility(ELI-NP). The specific activity for^(64)Cu was obtained as a function of target geometry, irradiation time, and electron beam energy, which translates into γ-beam energy. Optimized conditions for the generation of^(64)Cu isotopes at the ELI-NP were discussed. We estimated that an achievable saturation specific activity is of the order of 1–2 m Ci/g for thin targets(radius 1–2 mm,thickness 1 cm) and for a γ-beam flux of 10^(11) s ~1. Based on these results, the ELI-NP could provide great potential for the production of some innovative radioisotopes of medical interest in sufficient quantities suitable for nuclear medicine research.Copper-64 is a radioisotope of medical interest that could be used for positron emission tomography imaging and targeted radiotherapy of cancer. In this work, we investigated the possibility of producing the 64Cu isotope through a 65Cu（γ,n） reaction using high-intensity γ-beams produced at the Extreme Light Infrastructure-Nuclear Physics facility （ELI-NP）. The specific activity for 64Cu was obtained as a function of target geometry, irradiation time, and electron beam energy, which translates into γ-beam energy. Optimized conditions for the generation of 64Cu isotopes at the ELI-NP were discussed. We estimated that an achievable saturation specific activity is of the order of 1–2 mCi/g for thin targets （radius 1–2 mm, thickness 1 cm） and for a γ-beam flux of 1011 s-1. Based on these results, the ELI-NP could provide great potential for the production of some innovative radioisotopes of medical interest in sufficient quantities suitable for nuclear medicine research.

关 键 词：放射性同位素 设施生产 中子反应 射线束 正电子发射断层成像 医用 靶向治疗 基础设施 

分 类 号：R817[医药卫生—影像医学与核医学]