垂体腺瘤与DNA甲基化的研究进展  

Research Advances in Pituitary Adenoma and DNA Methylation

作　　者：位振清[1] 李阳[1] 李伟华[1] 娄佳成 张波[2] 

机构地区：[1]大连医科大学第一临床医学院神经外科,辽宁大连116011 [2]大连医科大学第二临床医学院神经外科,辽宁大连116000

出　　处：《中国医学科学院学报》2016年第4期475-479,共5页Acta Academiae Medicinae Sinicae

基　　金：国家自然科学基金(81372714)~~

摘　　要：DNA甲基化与垂体腺瘤的发生发展密切相关。有研究表明钾电压程控通道β2成员、O6-甲基鸟嘌呤-DNA甲基转移酶、棘皮动物微管相关蛋白、ras同族成员D、同源盒基因B1、NNAT和P16启动子区域的高甲基化抑制基因的转录表达,从而调控垂体腺瘤的增殖;DNA甲基化与侵袭性垂体腺瘤密切相关。因此,深入研究垂体腺瘤DNA甲基化的分子机制,将为垂体腺瘤的诊治提供一个新的策略。DNA methylation is closely related to the genesis and development of pituitary adenoma.Studies have shown that high methylation in the promoter region of potassium voltage-gated chanel,shaker related subfamily,beta member 2,O-6-methylguanine-DNA methyltransferase,echinoderm microtubule associated protein like 2,ras homolog family member D,homeobox B1,NNAT,and P16 inhibits the expression of these genes and regulates of the proliferation of pituitary adenoma. DNA methylation is also closely related to invasive pituitary adenoma. Therefore,further study on molecular mechanism of DNA methylation of pituitary adenoma will offer a new strategy for the diagnosis and treatment of pituitary adenoma.

关 键 词：DNA甲基化 垂体腺瘤 诊断 治疗 

分 类 号：R651[医药卫生—外科学]