早产儿先天性心脏病发病率及短期预后  

Incidence of congenital heart disease in preterm infants and the short-term outcomes

作　　者：王一飞[1] 申俊君[2] 何少茹[1] 梁穗新[1] 孙云霞[1] 王雪莲[1] 

机构地区：[1]广东省人民医院(广东省医学科学院)儿科,广州510100 [2]广东省心血管病研究所心儿科广东省华南结构性心脏病重点实验室广东省人民医院(广东省医学科学院),广州510100

出　　处：《岭南心血管病杂志》2016年第4期437-441,共5页South China Journal of Cardiovascular Diseases

基　　金：国家"十二五"科技支撑计划项目(项目编号:2011BA111B227)

摘　　要：目的研究先天性心脏病（congenitalheartdisease，CHD）在早产儿中的发病率及短期预后。方法回顾性收集广东省人民医院2009年1月至2013年12月收治的胎龄〈37周，且生后确诊存在除动脉导管未闭或房间隔缺损外的CHD早产儿资料。参考美国VON（VermontOxfordNetwork）的定义将CHD分类。收集所有患儿的一般情况、手术情况及短期预后。结果总共1406例早产儿中，48例（3．4％）存在CHD，严重CHD有25例（52．1％）。CHD早产儿胎龄为（33．1±2．7）周，出生体质量为（1828±614）g，男30例（62．5％），住院时间为18（10～42）d，出院时纠正胎龄为38（36～41）周。33例（68．8％）无需新生儿期手术。接受手术患儿的手术日龄为20（14～33）d，手术时纠正胎龄为38（36—39）周，手术时体质量为（2237±241）g。出院时宫外生长发育迟缓的发生率为65．9％。结论早产儿CHD发病率和病死率高，生后宫外生长发育迟缓比例高。过半数患儿无需手术或在新生儿期内无需手术。Objectives To determine the incidence of congenital heart disease （CHD） in preterm infants and the short- term outcomes. Methods The clinical data of preterrn infants hospitalized in Guangdong General Hospital from January 2009 to December 2013 were retrospectively reviewed. These preterm infants were diagnosed as CHD [except patent？ ductus arteriosus （PDA） or atrial septal defect] with gestational age less than 37 weeks. Diagnosis was classified based on the definition of CHD in Vermont Oxford Network. General information, surgery information and short-term outcomes of these infants were collected. Results Among 1 406 preterm infants documented, 48 （3.4%） infants were diagnosed as CHD including 25 cases （52.1% ） with severe CHD. The gestational age of these infants was （33.1 ±2.7） weeks, birth weight was （1828±614） g. Thirty cases （62.5%） were male. Duration of stay in hospital was 18 （10-42） days. Postmenstrual age （PMA） at discharge was 38 （36-41） weeks. For infants receiving surgery, age at surgery was 20 （14-33） days, PMA at surgery was 38 （36-39） weeks, weight at surgery was （2 237±241 ） g. Extrauterine growth retardation （EUGR） happened in 65.9% infants. Conclusions Incidence and mortality rate of CHD in preterm infants are high, with a high rate of EUGR. Surgical treatment in the first month is not necessarily in more than half of these infants.

关 键 词：先天性心脏病 早产儿 发病率 预后 

分 类 号：R541.7[医药卫生—心血管疾病]