盐酸氟哌噻吨合成工艺优化  

Improved Synthesis of Flupenthixol Dihydrochloride

作　　者：青磊 

机构地区：[1]贵州省药品评价中心,贵州贵阳550004

出　　处：《广东化工》2016年第15期67-68,共2页Guangdong Chemical Industry

摘　　要：以2-[4-三氟甲基-甲苯巯基]-苯甲酸为原料,经闭环反应、巴比耶反应、脱水重排后与羟基哌嗪缩合得到氟哌噻吨,最后与盐酸成盐得目标物氟哌噻吨盐酸盐。总收率44.3%。Flupenthixol dihydrochloride was synthesized from 2-[4-Trifluormethyl-phenylmercapto]-benzoesaeure by ring-closure reaction, Barbier reaction, rearrangement, and then condensation with N-（2-hydroxyethyl） piperazine in refluxed in alcohol, which salt formation to give the target product with an overall yield of 44.3 %.

关 键 词：盐酸氟哌噻吨 巴比耶反应 合成 

分 类 号：TQ[化学工程]